Journal of Lipid Research, 2017 We developed an in silico mathematical model of retinal cholesterol (Ch) dynamics (RCD) to quantify the physiological rate of Ch turnover in the rod outer segment (ROS), the lipoprotein transport mechanisms by which Ch enters and leaves the outer retina,
Seyedeh Maryam Zekavat +3 more
doaj
Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment. [PDF]
Kidney Int Rep, 2022 Ham YJ +14 more
europepmc +1 more source
Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration. [PDF]
, 2016 PurposeTo redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD).MethodsWe present a new potent peptide (Peptide 2) of the compstatin family.
Cabrera, Andrea P +6 more
core +1 more source
A variance components factor model for genetic association studies: a Bayesian analysis.
, 2010 Studies of gene-trait associations for complex diseases often involve multiple traits that may vary by genotype groups or patterns. Such traits are usually manifestations of lower-dimensional latent factors or disease syndromes.
Nonyane, BAS, Whittaker, JC
core +1 more source
Retinal hemorrhages as one of complications of optic disc drusen during pregnancy
Medicinski pregled, 2014 Introduction. Drusen of the optic nerve head are relatively benign and asymptomatic. They represent retinal hyaline corpuscles resulting from impaired axoplasmic transport of the retinal ganglion cells of optic nerve in front of the lamina cribrosa. They are usually detected accidentally, during a routine ophthalmologic examination.
Marija Trenkic-Bozinovic +5 more
openaire +3 more sources
Patients with MPNs and retinal drusen show signs of complement system dysregulation and a high degree of chronic low-grade inflammation. [PDF]
EClinicalMedicine, 2022 Liisborg C +4 more
europepmc +1 more source
Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers. [PDF]
, 2016 PurposeWe determined the phenotypic variation, disease progression, and potential modifiers of autosomal dominant retinal dystrophies caused by a splice site founder mutation, c.828+3A>T, in the PRPH2 gene.MethodsA total of 62 individuals (19 families)
Birch, David G +7 more
core
Molecular composition of drusen and possible involvement of anti‐retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey ( Macaca fascicularis ) [PDF]
, 2005 openalex +1 more source
Ophthalmology Science, 2021 Purpose: To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Design: Longitudinal population-based cohort study conducted from 2013 through 2017. Participants: Residents 40 years of
Miki Sato-Akushichi, MD +7 more
doaj
Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]
, 2015 The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja +6 more
core +1 more source