Results 1 to 10 of about 22,360 (228)

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

Journal of Extracellular Vesicles, 2021
Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide. Drusen are key contributors to the etiology of AMD and the ability to modulate drusen biogenesis could lead to therapeutic strategies to slow or halt AMD progression.
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti, M. Valeria Canto‐Soler   +17 more
doaj   +2 more sources

Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration

Frontiers in Medicine, 2021
Purpose: To observe the relationship between the characteristic changes in the drusen morphology revealed by the spectral-domain optical coherence tomography (SD-OCT) and the progression of age-related macular degeneration (AMD).Methods: A total of 380 ...
Shasha Yang, Zongyin Gao, Haijiang Qiu, Chengguo Zuo, Lan Mi, Hui Xiao, Xing Liu   +6 more
doaj   +2 more sources

Cuticular drusen: Age-related macular degeneration in the young - A case report

Indian Journal of Ophthalmology. Case Reports, 2021
A 30-year-old woman presented to the OPD, and during the course of her retinal examination she was seen to have multiple drusen in both the eyes.
Saarang Hansraj, Aliya Sultana, Rajalingam Vairagyam   +2 more
doaj   +2 more sources

Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population

Ophthalmology Science, 2021
Purpose: To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Design: Longitudinal population-based cohort study conducted from 2013 through 2017. Participants: Residents 40 years of
Miki Sato-Akushichi, MD, Reiko Kinouchi, MD, PhD, Satoshi Ishiko, MD, PhD, Kazuomi Hanada, MD, PhD, Hiroki Hayashi, Daiki Mikami, Shinji Ono, MD, PhD, Yasuo Yanagi, MD, PhD   +7 more
doaj   +2 more sources

Small hard drusen and associated factors in early seniority.

PLoS ONE, 2022
PurposeThe purpose of this study was to examine the ocular and systemic risk profile of the fundus phenotype ≥ 20 small hard (macular) drusen (< 63 μm in diameter).MethodsThis single-center, cross-sectional study of 176 same-sex twin pairs aged 30 to 80 (
Mohamed Belmouhand, Simon P Rothenbuehler, Sami Dabbah, Jakob Bjerager, Birgit Sander, Jacob B Hjelmborg, Christine Dalgård, Rasmus Jensen, Michael Larsen   +8 more
doaj   +1 more source

Drusen characteristics of type 2 macular neovascularization in age-related macular degeneration

BMC Ophthalmology, 2020
Background Type 2 macular neovascularization (MNV) is supposed to be a rare condition in age-related macular degeneration (AMD). The main purpose of this study was to assess accompanying factors of type 2 MNV in AMD.
Daniel Ahmed, Martin Stattin, Anna-Maria Haas, Alexandra Graf, Katharina Krepler, Siamak Ansari-Shahrezaei   +5 more
doaj   +1 more source

Evaluation of the microperimetry in eyes with cuticular drusen

Scientific Reports, 2022
Retinal sensitivity may vary by subtypes of cuticular drusen. This retrospective study included 52 eyes of 32 patients with cuticular drusen. All the patients underwent assessment of best-corrected visual acuity (BCVA), spectral-domain optical coherence ...
Seung Wan Nam, Jung Hwa Lee, Zeeyoon Byun, Don-Il Ham, Mingui Kong   +4 more
doaj   +1 more source

The HIT Study—The Hydroxychloroquine Effect in the Treatment of Patients with Age-Related Macular Degeneration: A Randomized Controlled Trial

Medicina, 2023
Background and Objectives: Decreased age-related macular degeneration (AMD) has been reported in individuals with rheumatoid arthritis treated with hydroxychloroquine (HCQ, plaquenil).
Tal Yahalomi, Yoav Pikkel, Roee Arnon, Dafi Porat, Joseph Pikkel   +4 more
doaj   +1 more source

Integrity of the Hyperreflective Layer in the Inner Choroid in Eyes with Drusen

Ophthalmology and Therapy, 2023
Introduction This study aimed to compare the integrity of the hyperreflective layer of the inner choroid in eyes with and without drusen. Methods Swept-source optical coherence tomography images of patients with drusen and normal controls were reviewed ...
Young Ho Kim, Cheolmin Yun, Jaeryung Oh
doaj   +1 more source

Clinical manifestations of cuticular drusen in Korean patients

Scientific Reports, 2020
Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows
Dong Hoon Shin, Mingui Kong, Gyule Han, Jong Chul Han, Don-Il Ham   +4 more
doaj   +1 more source