Results 21 to 30 of about 22,360 (228)

Optic Nerve Drusen Evaluation: A Comparison between Ultrasound and OCT

Journal of Clinical Medicine, 2022
This observational study compared optic coherence tomography (OCT) and B-scan in the detection of optic disc drusen. In total, 86 eyes of 50 patients with optic disc drusen (ODD) (36 bilateral) with a mean age of 34.68 ± 23.81 years, and 54 eyes of 27 ...
N. Rosa, Maddalena De Bernardo, Giulia Abbinante, G. Vecchio, Ferdinando Cione, L. Capasso   +5 more
semanticscholar   +1 more source

Cuticular Drusen in Age-Related Macular Degeneration: Association with Progression and Impact on Visual Sensitivity.

Ophthalmology (Rochester, Minn.), 2022
PURPOSE To determine the prognostic significance and impact on visual function of the cuticular drusen phenotype in a cohort with intermediate age-related macular degeneration (AMD). DESIGN Longitudinal observational study.
K. Goh, F. Chen, Chandrakumar Balaratnasingam, C. Abbott, L. Hodgson, R. Guymer, Zhichao Wu   +6 more
semanticscholar   +1 more source

Topographic Distribution and Progression of Soft Drusen Volume in Age-Related Macular Degeneration Implicate Neurobiology of Fovea

Investigative Ophthalmology and Visual Science, 2021
Purpose To refine estimates of macular soft drusen abundance in eyes with age-related macular degeneration (AMD) and evaluate hypotheses about drusen biogenesis, we investigated topographic distribution and growth rates of drusen by optical coherence ...
A. Pollreisz, G. Reiter, Hrvoje Bogunović, L. Baumann, Astrid Jakob, F. Schlanitz, S. Sacu, C. Owsley, K. Sloan, C. Curcio, U. Schmidt-Erfurth   +10 more
semanticscholar   +1 more source

Extramacular Drusen and Progression of Age-related Macular Degeneration (AMD); Age-related Eye Disease Study 2 Report 30

Ophthalmology Retina, 2022
Purpose: To identify the prevalence of drusen outside the macula and their role in progression of age-related macular degeneration (AMD). Design: Retrospective analysis of a prospective cohort study Participants: 4168 eyes (2998 participants) with ...
A. Domalpally, Bohan Xing, Jeong W. Pak, E. Agrón, F. Ferris, T. Clemons, E. Chew   +6 more
semanticscholar   +1 more source

Characterization of Drusen and Hyperreflective Foci as Biomarkers for Disease Progression in Age-Related Macular Degeneration Using Artificial Intelligence in Optical Coherence Tomography.

JAMA ophthalmology, 2020
Importance The morphologic changes and their pathognomonic distribution in progressing age-related macular degeneration (AMD) are not well understood. Objectives To characterize the pathognomonic distribution and time course of morphologic patterns in ...
S. Waldstein, Wolf-Dieter Vogl, Hrvoje Bogunović, A. Sadeghipour, Sophie Riedl, U. Schmidt-Erfurth   +5 more
semanticscholar   +1 more source

Cytokine profiles of macular neovascularization in the elderly based on a classification from a pachychoroid/drusen perspective

Graefe's Archive for Clinical and Experimental Ophthalmology, 2021
To classify macular neovascularization (MNV) based on pachychoroid and drusen features and to examine the aqueous humor cytokine signatures of each group. In total, 106 consecutive eyes with treatment-naïve MNV and 104 control eyes were examined.
S. Inoda, Hidenori Takahashi, Yuji Inoue, Xue Tan, Hironobu Tampo, Y. Arai, Y. Yanagi, H. Kawashima   +7 more
semanticscholar   +1 more source

Validation of a Novel Automated Algorithm to Measure Drusen Volume and Area Using Swept Source Optical Coherence Tomography Angiography

Translational Vision Science & Technology, 2021
Purpose The purpose of this study was to validate a novel automated swept source optical coherence tomography angiography (SS-OCTA) algorithm to measure elevations of the retinal pigment epithelium (RPE) in eyes with nonexudative age-related macular ...
Xiaoshuang Jiang, Mengxi Shen, Liang Wang, L. de Sisternes, M. Durbin, W. Feuer, P. Rosenfeld, Giovanni Gregori   +7 more
semanticscholar   +1 more source

Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis. [PDF]

PLoS ONE, 2016
Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness ...
Koji M Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa   +11 more
doaj   +1 more source

The Proteomics of Drusen [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
The formation of extracellular deposits known as drusen below the macular region of the retina correlates with increased risk of severe visual loss from age-related macular degeneration (AMD). Inflammation and complement dysregulation contribute to AMD progression; however, disease mechanisms remain incompletely defined.
openaire   +2 more sources

Dynamic Drusen Remodelling in Participants of the Nutritional AMD Treatment-2 (NAT-2) Randomized Trial. [PDF]

PLoS ONE, 2016
PURPOSE:To evaluate the dynamic remodeling of drusen in subjects with unilateral neovascular age-related macular degeneration (AMD) receiving a three-year course of oral docosahexaenoic acid (DHA) or placebo. SETTING:Institutional setting.
Giuseppe Querques, Bénédicte M J Merle, Nicole M Pumariega, Pascale Benlian, Cécile Delcourt, Alain Zourdani, Heather B Leisy, Michele D Lee, R Theodore Smith, Eric H Souied   +9 more
doaj   +1 more source