Results 31 to 40 of about 15,961 (225)

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices.
Davide Garzone, Jan Henrik Terheyden, Olivier Morelle, Maximilian W. M. Wintergerst, Marlene Saßmannshausen, Steffen Schmitz-Valckenberg, Maximilian Pfau, Sarah Thiele, Stephen Poor, Sergio Leal, Frank G. Holz, Robert P. Finger, MACUSTAR Consortium   +12 more
doaj   +1 more source

Drusen-like, sub-RPE deposition, and RPE vacuolization in aged Cxcr5^-/- mice.

, 2017
Retinal cross sections were prepared from 17-month-old Cxcr5-/- mice (A-D) and C57BL/6 WT control mice (E and F). Cryo-preserved sections were stained with H & E (A, C, and E). Plastic sections were stained with toluidine blue (B, D, and F).
Lei Wang (6656), Ying Liu (18461), Wen Li (143214), Hu Huang (349397)   +3 more
core   +1 more source

Imaging Methods in the Diagnosis of Optic Disc Drusen

, 2016
Optic disc drusen (ODD) are benign congenital anomalies of the optic nerve characterized by calcified hyaline bodies. While superficial drusen can be diagnosed easily during fundus examination, detecting buried drusen requires the use of additional ...
Hakan Özdemir, Betül Tuğcu
core   +1 more source

Radiomic Characterization and Automated Classification of Drusen Substructure Phenotype Associated with High-Risk Dry Age-Related Macular Degeneration

Diagnostics
Background/Objectives: Optical coherence tomography (OCT)-reflective drusen substructures (ODSs) are associated with the conversion of intermediate AMD to geographic atrophy (GA). However, ODSs must be manually identified, a laborious process introducing
Scott W. Perkins, Neal Shah, Jon Whitney, Karen Matar, Hannah J. Yu, Charles C. Wykoff, Justis P. Ehlers   +6 more
doaj   +1 more source

Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes

Scientific Reports, 2021
This study aimed to quantify the Haller vessel and choriocapillaris (CC) parameters in drusen subtypes in nonexudative age-related macular degeneration (AMD) and pachydrusen.
Hyungwoo Lee, Seungmin Kim, Myung Ae Kim, Young Joon Jo, Woo Hyuk Lee, Hyung Chan Kim, Hyewon Chung   +6 more
doaj   +1 more source

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects

International Journal of Retina and Vitreous
Background Subretinal drusenoid deposits (SDDs), cuticular drusen, and calcified drusen have been linked to rapid progression of age-related macular degeneration (AMD). SDDs have also been linked to high-risk vascular diseases (HRVDs).
John M. Tan, Yang Fei, Liang Wang, Oscar Otero-Marquez, Tasin R. Bhuiyan, J. Fernando Arevalo, Gareth M.C. Lema, Roland Theodore Smith   +7 more
doaj   +1 more source

Diabetic Retinopathy in Primary Healthcare in a Brazilian Municipality: A Cross‐Sectional Study Using Teleophthalmology

Health Care Science, EarlyView.
The prevalence of diabetic retinopathy was estimated to be 28.3% (95% CI 21.1–35.4), with most of the cases corresponding to mild non‐proliferative diabetic retinopathy. ABSTRACT Background Diabetic retinopathy is a complication of diabetes and the leading cause of irreversible blindness in people of working age.
Lorrana Luysse dos Anjos Assis, Fernando Korn Malerbi, Rosiane Chiaroti, Lívia Maria Ferrante Vizzotto Consoli, Vanessa Patrícia Pereira Motozo, Francisco Barbosa‐Junior, Rinaldo Eduardo Machado de Oliveira   +6 more
wiley   +1 more source

Developing an image-based grading scale for peripheral drusen to investigate associations of peripheral drusen type with age-related macular degeneration

Scientific Reports
Age-related macular degeneration (AMD) is a leading cause of blindness. It is associated with peripheral drusen which has not been categorized. We investigated peripheral drusen to validate an image grading system and to understand possible associations ...
Paripoorna Sharma, Fritz Gerald P. Kalaw, Andrew Lin, Evan H. Walker, Shyamanga Borooah   +4 more
doaj   +1 more source

Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model

Nature Communications, 2021
Age-related macular degeneration is characterized by lipid-rich drusen deposits underneath the retinal pigment epithelium (RPE). Here the authors report an in vitro iPSC-RPE model for AMD that recapitulates drusen and RPE atrophy, and identify two drugs ...
Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti   +22 more
doaj   +1 more source