Results 41 to 50 of about 22,360 (228)

Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies

Investigative Ophthalmology and Visual Science, 2018
AMD is a major cause of legal blindness in older adults approachable through multidisciplinary research involving human tissues and patients. AMD is a vascular-metabolic-inflammatory disease, in which two sets of extracellular deposits, soft drusen/basal
C. Curcio
semanticscholar   +1 more source

Exploration of cuticular drusen: comprehensive analysis from multi-modal imaging characteristics to clinical diagnosis and treatment

Yanke Xuebao
With the application of multimodal imaging techniques, a specific subtype of age-related macular degeneration (AMD), known as cuticular drusen, has been identified.
ZHANG Guanghan, ZHANG Xiongze, JI Yuying
doaj   +1 more source

Comparability of automated drusen volume measurements in age-related macular degeneration: a MACUSTAR study report

Scientific Reports, 2022
Drusen are hallmarks of early and intermediate age-related macular degeneration (AMD) but their quantification remains a challenge. We compared automated drusen volume measurements between different OCT devices.
Davide Garzone, Jan Henrik Terheyden, Olivier Morelle, Maximilian W. M. Wintergerst, Marlene Saßmannshausen, Steffen Schmitz-Valckenberg, Maximilian Pfau, Sarah Thiele, Stephen Poor, Sergio Leal, Frank G. Holz, Robert P. Finger, MACUSTAR Consortium   +12 more
doaj   +1 more source

Autophagy in drusen biogenesis secondary to age‐related macular degeneration

Acta ophthalmologica
Age‐related macular degeneration (AMD) is an emerging cause of blindness in aged people worldwide. One of the key signs of AMD is the degeneration of the retinal pigment epithelium (RPE), which is indispensable for the maintenance of the adjacent ...
J. Hyttinen, A. Koskela, J. Błasiak, K. Kaarniranta   +3 more
semanticscholar   +1 more source

Prevalence and histopathological signatures of optic disc drusen based on microscopy of 1713 enucleated eyes

Acta ophthalmologica, 2020
Optic disc drusen (ODD) are calcified optic nerve head deposits. Objectives of this study were to examine the prevalence of ODD in eyes removed by enucleation and to describe related histopathological signatures of ODD and surrounding tissues.
M. Skougaard, S. Heegaard, L. Malmqvist, S. Hamann   +3 more
semanticscholar   +1 more source

A COMPREHENSIVE REVIEW ON EARLY DETECTION OF DRUSEN PATTERNS IN AGE-RELATED MACULAR DEGENERATION USING DEEP LEARNING MODELS.

Photodiagnosis and Photodynamic Therapy
Age-related Macular Degeneration (AMD) is a leading cause of visual impairment and blindness that affects the eye from the age of fifty-five and older. It impacts on the retina, the light-sensitive layer of the eye.
K. M, Malathi G
semanticscholar   +1 more source

Integrative analysis of the choroid by quantifying Haller vessel and choriocapillaris parameters in different drusen subtypes

Scientific Reports, 2021
This study aimed to quantify the Haller vessel and choriocapillaris (CC) parameters in drusen subtypes in nonexudative age-related macular degeneration (AMD) and pachydrusen.
Hyungwoo Lee, Seungmin Kim, Myung Ae Kim, Young Joon Jo, Woo Hyuk Lee, Hyung Chan Kim, Hyewon Chung   +6 more
doaj   +1 more source

Drusen in AMD from the Perspective of Cholesterol Metabolism and Hypoxic Response

Journal of Clinical Medicine
Drusen are one of the most characteristic pathologies of precursor lesion of age-related macular degeneration (AMD). Drusen comprise a yellowish white substance that accumulates typically under the retinal pigment epithelium (RPE), and their constituents
Norimitsu Ban, A. Shinojima, K. Negishi, T. Kurihara   +3 more
semanticscholar   +1 more source

Radiomic Characterization and Automated Classification of Drusen Substructure Phenotype Associated with High-Risk Dry Age-Related Macular Degeneration

Diagnostics
Background/Objectives: Optical coherence tomography (OCT)-reflective drusen substructures (ODSs) are associated with the conversion of intermediate AMD to geographic atrophy (GA). However, ODSs must be manually identified, a laborious process introducing
Scott W. Perkins, Neal Shah, Jon Whitney, Karen Matar, Hannah J. Yu, Charles C. Wykoff, Justis P. Ehlers   +6 more
doaj   +1 more source

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source