Results 61 to 70 of about 22,360 (228)

Drusen, an Old but New Frontier [PDF]

Retina, 2010
Early in the education of ophthalmologists the student is introduced to the concept of drusen. The material is presented in an efficient unquestioning manner: drusen are formed by material under the retinal pigment epithelium (RPE). This material seems to have varying composition, which may have clinically recognizable correlates.1-4 Classification ...
Spaide, R F, Curcio, C A, Zweifel, S A
openaire   +2 more sources

Radial outer retina reflectivity (RORR) sign in LAMP2‐associated retinopathy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To describe the radial outer retina reflectivity (RORR) sign in patients carrying pathogenic variants in the X‐linked lysosome‐associated membrane protein‐2 (LAMP2) gene and to review the histologic characteristics of LAMP2 expression in the human retina.
Rachael C. Heath Jeffery, Bohdan Kousal, Ulrike Grünert, Christine A. Curcio, Svetlana Cherepanoff, Tina M. Lamey, Michel Michaelides, Chrysanthi Tsika, Isabelle Chow, Omar A. Mahroo, Seungmin Lee, Martin Meliska, Milos Kubanek, Jakub Sikora, Siying Lin, Raymond C. B. Wong, Petra Liskova, Fred K. Chen   +17 more
wiley   +1 more source

Drusen, AMD, and history [PDF]

Graefe's Archive for Clinical and Experimental Ophthalmology, 2015
It is becoming increasingly difficult to get manuscripts on (ophthalmic) history accepted by medical journals. This, in spite of the fact that studying the history of disorders yields valuable insights, which can offer new approaches to solving problems of pathophysiology or delimiting disease entities.
openaire   +3 more sources

Clinical manifestations of dual‐gene variants in retinitis pigmentosa

Acta Ophthalmologica, EarlyView.
Abstract Purpose Retinitis pigmentosa (RP) is an inherited retinal disease (IRD), whereby each affected individual typically harbours pathogenic variants in a single causative gene, yet the disorder exhibits marked genetic heterogeneity, with more than 100 genes reported to underlie RP.
Lasse Wolfram, Jan‐Philipp Bodenbender, David A. Merle, Milda Reith, Anton Sonntag, Krunoslav Stingl, Tobias B. Haack, Theresia Zuleger, Bernd Wissinger, Laura Kühlewein, Katarina Stingl, Susanne Kohl   +11 more
wiley   +1 more source

Stages of drusen-associated atrophy in age-related macular degeneration visible via histologically validated fundus autofluorescence

Ophthalmology Retina, 2020
Purpose: To determine histologic correlates for defined stages of drusen-associated atrophy observed with multimodal imaging including fundus autofluorescence (FAF) and color fundus photography (CFP) of eyes with advanced age-related macular degeneration
Ling Chen, J. Messinger, Daniela Ferrara, K. B. Freund, C. Curcio   +4 more
semanticscholar   +1 more source

Retinal dystrophies simulating geographic atrophy: A diagnostic challenge

Acta Ophthalmologica, EarlyView.
Abstract Geographic atrophy (GA) is the chronic loss of retinal pigment epithelium, photoreceptors and choriocapillaris, marking the dry late stage of age‐related macular degeneration (AMD). GA prevalence is expected to rise in the upcoming decades. Advanced GA leads to central scotomas, reducing visual acuity and quality of life, potentially resulting
Johanna M. Colijn, Frank G. Holz, Jeroen Pas, Carel Hoyng   +3 more
wiley   +1 more source

Diagnosing Optic Disc Drusen in the Modern Imaging Era: A Practical Approach

Neuro-ophthalmology (Aeolus Press. 1980), 2020
Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the
F. Costello, SP Rothenbuehler, P. Sibony, S. Hamann   +3 more
semanticscholar   +1 more source

Abundant lipid and protein components of drusen. [PDF]

PLoS ONE, 2010
Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE ...
Lan Wang, Mark E Clark, David K Crossman, Kyoko Kojima, Jeffrey D Messinger, James A Mobley, Christine A Curcio   +6 more
doaj   +1 more source

Bilaterality of drusen. [PDF]

British Journal of Ophthalmology, 1990
The characteristics of drusen in 81 patients with bilateral drusen as a manifestation of age related disease were analysed for symmetry between the two eyes. It was found that there was close concordance with respect to drusen size, number, density, and fluorescence which was greater than would have been expected by chance alone.
M, Barondes, D, Pauleikhoff, I C, Chisholm, D, Minassian, A C, Bird   +4 more
openaire   +2 more sources

Systematic quantification of outer retinal morphology in three different SD‐OCT devices in geographic atrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To define interdevice differences in quantitative outer retinal biomarkers across three spectral‐domain (SD) optical coherence tomography (OCT) devices in geographic atrophy (GA). Methods Patients with GA prospectively underwent imaging using Spectralis (Heidelberg Engineering), Cirrus (Zeiss) and Maestro (Topcon) OCT devices ...
Klaudia Birner, Sophie Frank‐Publig, Julia Mai, Anna Eidenberger, Johannes Schrittwieser, Gabriel Leitner‐Barrios, Magdalena Barasits, Markus Gumpinger, Gregor S. Reiter, Stefan Sacu, Ursula Schmidt‐Erfurth   +10 more
wiley   +1 more source