Results 11 to 20 of about 15,961 (225)

Glycoproteins of drusen and drusen-like lesions

Journal of Molecular Histology, 2007
Abstract Purpose: Drusen are a marker of age‐related macular degeneration. Lesions similar to drusen, both in histology and their clinical appearance are also seen in choroidal tumours, chronic inflammatory and degenerative conditions of the eye, and in mesangiocapillary glomerulonephritis type II (MCGN‐II).
D'Souza, Yvonne, Jones, C. J P; id_orcid 0000-0002-0026-9494, Bonshek, Richard   +2 more
openaire   +4 more sources

Drusen of the optic disc

Current Neurology and Neuroscience Reports, 2008
Optic disc drusen are acellular calcific deposits occurring in small, crowded optic discs with abnormal vasculature. Evidence suggests axoplasmic transport alteration and axonal degeneration are involved in disc drusen formation. In affected patients, the number and size of disc drusen are highly variable, and the drusen may be visible near the disc ...
Byron L, Lam, Christopher G, Morais, Joshua, Pasol   +2 more
openaire   +3 more sources

Photodegradable Hydrogels for On-Demand Modeling of Age-Related Spatiotemporal ECM Deformation. [PDF]

Small
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Reul F, Bergerbit C, Scarlat I, Piskova T, Krishnamurthy VT, Kozyrina AN, Yam SLS, De Laporte L, Di Russo J.   +8 more
europepmc   +2 more sources

Integrity of the Hyperreflective Layer in the Inner Choroid in Eyes with Drusen

Ophthalmology and Therapy, 2023
Introduction This study aimed to compare the integrity of the hyperreflective layer of the inner choroid in eyes with and without drusen. Methods Swept-source optical coherence tomography images of patients with drusen and normal controls were reviewed ...
Young Ho Kim, Cheolmin Yun, Jaeryung Oh
doaj   +1 more source

Population-Based Prevalence and 5-Year Change of Soft Drusen, Pseudodrusen, and Pachydrusen in a Japanese Population

Ophthalmology Science, 2021
Purpose: To elucidate the prevalence of soft drusen, pseudodrusen, and pachydrusen and their 5-year changes in a Japanese population. Design: Longitudinal population-based cohort study conducted from 2013 through 2017. Participants: Residents 40 years of
Miki Sato-Akushichi, MD, Reiko Kinouchi, MD, PhD, Satoshi Ishiko, MD, PhD, Kazuomi Hanada, MD, PhD, Hiroki Hayashi, Daiki Mikami, Shinji Ono, MD, PhD, Yasuo Yanagi, MD, PhD   +7 more
doaj   +1 more source

Diagnosing Optic Disc Drusen in the Modern Imaging Era:A Practical Approach

, 2021
Optic disc drusen (ODD) are a well-recognised cause of an elevated optic disc appearance. When visible with ophthalmoscopy and fundus photography, ODD are readily identified. Yet, in more subtle cases of ODD, ancillary testing may be needed to render the
Sibony, P. A., Rothenbuehler, S. P., Hamann, S., Costello, F., the Optic Disc Drusen Studies Consortium, Optic Disc Drusen Studies Consortium   +4 more
core   +1 more source

Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis. [PDF]

PLoS ONE, 2016
Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness ...
Koji M Nishiguchi, Yu Yokoyama, Yusuke Fujii, Kosuke Fujita, Yusuke Tomiyama, Ryo Kawasaki, Toshinori Furukawa, Fumiko Ono, Nobuhiro Shimozawa, Mutsumi Togo, Michihiro Suzuki, Toru Nakazawa   +11 more
doaj   +1 more source

Clinical manifestations of cuticular drusen in Korean patients

Scientific Reports, 2020
Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows
Dong Hoon Shin, Mingui Kong, Gyule Han, Jong Chul Han, Don-Il Ham   +4 more
doaj   +1 more source

The Proteomics of Drusen [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
The formation of extracellular deposits known as drusen below the macular region of the retina correlates with increased risk of severe visual loss from age-related macular degeneration (AMD). Inflammation and complement dysregulation contribute to AMD progression; however, disease mechanisms remain incompletely defined.
openaire   +2 more sources

Dynamic Drusen Remodelling in Participants of the Nutritional AMD Treatment-2 (NAT-2) Randomized Trial. [PDF]

PLoS ONE, 2016
PURPOSE:To evaluate the dynamic remodeling of drusen in subjects with unilateral neovascular age-related macular degeneration (AMD) receiving a three-year course of oral docosahexaenoic acid (DHA) or placebo. SETTING:Institutional setting.
Giuseppe Querques, Bénédicte M J Merle, Nicole M Pumariega, Pascale Benlian, Cécile Delcourt, Alain Zourdani, Heather B Leisy, Michele D Lee, R Theodore Smith, Eric H Souied   +9 more
doaj   +1 more source