Results 91 to 100 of about 9,112 (206)

CLRN1 Variants in Müller Cells Cause Mitochondrial Dysfunction in USH3A Retinal Organoids

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
We generated retinal organoids from a patient with USH3A and performed single‐cell RNA sequencing. CLRN1 was specifically expressed in Müller cells, where its variants led to mitochondrial dysfunction and photoreceptor degeneration. ABSTRACT Background Usher syndrome 3A (USH3A), caused by mutations in the CLRN1 gene, leads to retinitis pigmentosa and ...
Rui Zhang, Xinbo Ji, Han Yu, Jingwen Xu, Yu Wang, Ping Sun, Yingxin Wang, Yao Tang, Zexin Zhan, Yichang Jiao, Didi Shan, Pengfei Lin, Dong‐dong Wang, Yuying Zhao, Xianyang Liu, Chuanzhu Yan, Jianqiao Li, Mingfeng Li, Fuchen Liu, Shengping Hou   +19 more
wiley   +1 more source

Adult-onset Foveomacular Vitelliform Dystrophy

Okulistyka
Adult-onset foveomacular vitelliform dystrophy is one of the most common macular dystrophies, classified within the group of pattern dystrophies. The condition typically arises after the fourth decade of life and manifests with subretinal vitelliform ...
Michał Jabłoński, Jerzy Mackiewicz
doaj   +1 more source

Expanding the Genotypic Spectrum of POMGNT1‐Related Muscle‐Eye‐Brain Disease: A Case Report

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
Compound heterozygous variants in the POMGNT1 gene expand the genotypic spectrum of Muscle‐Eye‐Brain disease, highlighting severe epilepsy with status epilepticus. Despite long disease duration, seizure freedom was achieved with intensive antiseizure polytherapy, underscoring the importance of continued therapeutic optimization in dystroglycanopathies.
Evripidis Pityrigkas, Vasiliki Poulidou, Stefania Kalampokini, Eleni Liouta, Georgia Pepe, Martha Spilioti, Vasilios K. Kimiskidis   +6 more
wiley   +1 more source

Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy

Optometry and Vision Science, Volume 103, Issue 8, August 2026.
ABSTRACT Purpose To highlight retinal ischemia as an important component of diabetic retinopathy (DR) pathogenesis, a significant prognostic factor, and a driver of various DR complications, including neovascularization. We aim to describe the main features of ischemic areas that can be identified through fundoscopy, color fundus photography, optical ...
Marina Guro, Henrietta Wang, Jack Phu, Kaitlyn A. Sapoznik, Hamza Shah, Maggie L. Zhang, Michael Kalloniatis   +6 more
wiley   +1 more source

Advancing Treatment of Degenerative Eye Diseases at the Nanoscale

Smart Medicine, Volume 5, Issue 4, August 2026.
Nanotherapeutics possess the potential to overcome longstanding bottlenecks in treating degenerative ophthalmic diseases. With a highly tunable surface chemistry, nanotechnology platforms can be customized to navigate specific anatomical barriers in the eye and target pathways of diseases.
Li Yao Jin, Evashiniee G. P. Selvam, Qinsong Mei, Chi D. Luu, Yeannie H. Y. Yap, Daniel B. L. Teh   +5 more
wiley   +1 more source

Injectable Artificial Photoreceptors: STEM Cell Functional Integration and in vivo Electrophysiological Validation in Retinal Degeneration Models

Small Science, Volume 6, Issue 8, August 2026.
Artificial photoreceptors are engineered to efficiently absorb light, with the strongest sensitivity in the green region of the visible spectrum. Upon illumination, they generate electrical signals that activate retinal ganglion cells, which are typically unaffected by disease, enabling transmission of visual information to the brain.
Afshin Izadian, Ali Torkashvand, Benjamin Allan McCall, Yong Gao, Christine M. Taylor, Fateme Karimi Hafshejani, Arupratan Das, Michelle L. Surma, Sunland Gong, Amir Reza Hajrasouliha   +9 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Dissecting PDE6-Associated Inherited Retinal Dystrophies Using Patient-Derived Retinal Models

Organoids
Inherited retinal dystrophies (IRDs) comprise a diverse group of genetic disorders that frequently result in irreversible vision loss due to photoreceptor dysfunction or degeneration. Among them, retinitis pigmentosa (RP) and achromatopsia (ACHM) are, in
Paula Gaudó, Anniken Burés-Jelstrup, Laura Siles, Rafael Navarro, Esther Pomares   +4 more
doaj   +1 more source

Ray‐Tracing‐Based Intraocular Lens Power Calculation in Combined Cataract Surgery and Descemet Membrane Endothelial Keratoplasty

Clinical &Experimental Ophthalmology, Volume 54, Issue 6, Page 769-778, August 2026.
ABSTRACT Background To compare the predictive accuracy of ray tracing‐based intraocular lens (IOL) power calculation formulas with the Barrett Universal II (BUII) formula in eyes with Fuchs endothelial corneal dystrophy (FECD) undergoing combined cataract surgery and Descemet membrane endothelial keratoplasty (triple DMEK).
Jan O. Weber, Klemens P. Kaiser, Jascha A. Wendelstein, H. Burkhard Dick, Thomas Kohnen, Ingo Schmack   +5 more
wiley   +1 more source

Expanding horizons of intravitreal anti-vascular endothelial growth factor therapy in retinal diseases

Indian Journal of Ophthalmology
Vascular endothelial growth factor (VEGF) plays a central role in the pathogenesis of retinal and choroidal neovascularization, as well as macular edema (ME), in retinal disorders such as diabetic retinopathy, retinal vein occlusion (RVO), and age ...
Shalini Singh, Urvashi Kala, Arjun Bamel, Manisha Agarwal   +3 more
doaj   +1 more source