Results 91 to 100 of about 654,251 (322)

Presumed choroidal metastasis from soft tissue myoepithelial carcinoma [PDF]

, 2019
Purpose: To report a case of presumed choroidal metastasis from soft tissue myoepithelial carcinoma and highlight challenges in its diagnosis. Observations: A 52-year-old man was referred with a two-week history of photopsia in his left eye.
Bonar, Fiona, Fung, Adrian T, Hong, Angela M, Hui, Michelle M, Merani, Rohan   +4 more
core   +1 more source

Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages.: DLL4's opposing effects in choroidal neovascularization [PDF]

, 2012
International audienceInflammatory neovascularization, such as choroidal neovascularization (CNV), occur in the presence of Notch expressing macrophages. DLL4s anti-angiogenic effect on endothelial cells (EC) has been widely recognized, but its influence
Calippe, Bertrand, Camelo, Serge, Cristofaro, Brunella, Devevre, Estelle, Duarte, Antonio, Eichmann, Anne, Guillonneau, Xavier, Houssier, Marianne, Jonet, Laurent, Klein, Christophe, Lavalette, Sophie, Leconte, Laurence, Levy, Olivier, Raoul, William, Sennlaub, Florian, Sulpice, Eric, Thuret, Gilles   +16 more
core   +4 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Neoplasms of the Internal Auditory Canal [PDF]

, 1971
Histopathological studies of tumors of the temporal bone are scarce. The authors examined a relatively large number of sectioned human temporal bones in search of small asymptomatic acoustic neurilemmomata and have reported the findings (Leonard and ...
Leonard, James R., Talbot, Marion L.
core   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

The role of optical coherence tomography in the evaluation of para-chiasmal lesions: a systematic review and meta-analysis

Frontiers in Ophthalmology
IntroductionWhile magnetic resonance imaging is currently the primary diagnostic tool for pituitary tumors, optical coherence tomography (OCT) may be used in evaluating the visual pathway impact of these lesions.
Khai Shin Alva Lim, Wen Xu Abel Tng, Wei De Bryan Theng, Bernett Teck Kwong Lee, Chee Fang Chin, Kelvin Zhenghao Li, Kelvin Zhenghao Li, Kelvin Zhenghao Li, Heather E. Moss, Heather E. Moss   +9 more
doaj   +1 more source

Mapping gene associations in human mitochondria using clinical disease phenotypes [PDF]

, 2009
Nuclear genes encode most mitochondrial proteins, and their mutations cause diverse and debilitating clinical disorders. To date, 1,200 of these mitochondrial genes have been recorded, while no standardized catalog exists of the associated clinical ...
A Hamosh, A Spinazzola, AJ Butte, Andrey Rzhetsky, BB Lowell, C Eng, C Perez-Cerda, Curt Scharfe, D Skladal, DC Wallace, E Singer, Edward A. Allen, FW Sabb, G Benard, G Giaever, GM Enns, Gregory M. Enns, Guan-Cheng Li, H Prokisch, H Prokisch, Henry Horng-Shing Lu, HG Brunner, I Feldman, IH Witten, J Lim, JB Potash, JD Storey, JO Sass, Jutta K. Neuenburg, K Lage, KI Goh, L Franke, LG Biesecker, LM Steinmetz, MA Holliday, MA van Driel, MG Rosca, N Darin, N Freimer, O Elpeleg, P Braun, PF Chinnery, PM Nadkarni, R Delsite, R Ensenauer, R Luft, Ronald W. Davis, S Anderson, S Calvo, S DiMauro, SE Calvano, T Hernandez-Boussard, TD Vo, Thomas Klopstock, Tina M. Cowan, TM Dawson, V Tiranti, VK Mootha   +57 more
core   +5 more sources