Results 101 to 110 of about 37,318 (280)

An n‐of‐1 gene‐directed drug repurposing trial for an ultrarare genetic condition

Epilepsia, EarlyView.
Abstract Objective Gain‐of‐function (GoF) variants in the KCNC1 potassium channel subunit gene (Kv3.1) cause motor/cognitive delays and hypotonia and have been associated with seizures. Fluoxetine has inhibitory effects on Kv3.1. However, open‐label nonrandomized administration is insufficient to guide clinical decision‐making in ultrarare conditions ...
Vedika Jha, Christina Tsetsos, Mark Bedford, Gregory Costain, Sunita Vohra, Juan Pablo Diaz Martinez, Elise Heon, Jacob Vorstman, Carolina Gorodetsky, Ajoy Vincent, Jesiqua Rapley, Lori Anderson, Evdokia Anagnostou, Danielle A. Baribeau   +13 more
wiley   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

A real-world pharmacovigilance analysis of the risk of retinal artery occlusion from medication use

AJO International
Purpose: The risk of retinal artery occlusion (RAO) as related to specific drug use is unclear. Using the Food and Drug Administration Adverse Event Reporting System (FAERS), we aimed to comprehensively elicit a list of FDA-approved drugs overreported ...
Andrew Mihalache, Ryan S. Huang, Marko M. Popovic, Kirill Zaslavsky, David Sarraf, SriniVas R. Sadda, Rajeev H. Muni, Edward A. Margolin   +7 more
doaj   +1 more source

Brain–Computer Interfaces: The Dawn of a New Era in Disease Treatment

Exploration, EarlyView.
This study investigates the potential of brain–computer interface (BCI) technology in treating neuropsychiatric disorders, such as movement and communication barriers. Our review examines the history, signal paradigms, and diverse applications of BCI while also discussing ongoing research into novel materials and emerging technologies that offer ...
Yuqi Feng, Wangzheqi Zhang, Jun Chen, Huang Wu, Lei Wu, Yanhao Qiu, Xiaoming Deng, Chenglong Zhu, Yisheng Chen, Zhijie Zhao, Changli Wang, Xiaomin Zhang   +11 more
wiley   +1 more source

Cell cultures of human ciliary muscle: growth, ultrastructural and immunocytochemical characteristics

, 1991
Primary ciliary muscle cell cultures derived from human donors (16-91 years) were established and characterized by comparing them with ciliary muscle in tissue sections using immunocytochemical and ultrastructural methods.
Baur, A., Tamm, Ernst R., Flügel, C., Lütjen-Drecoll, E.   +3 more
core   +1 more source

Safety Profile of Sclerosing Agents in the Management of Low‐Flow Vascular Malformations of the Head and Neck—A Systematic Review

Head &Neck, EarlyView.
ABSTRACT Background Low‐flow vascular malformations (LFVMs) of the head and neck, including venous and lymphatic malformations, represent a heterogeneous group of congenital anomalies frequently requiring intervention due to functional and esthetic impairment.
Riccardo Nocini, Carlotta Muneretto, Athena E. Arsie, Valerio Arietti, Benedetta Lorenzon, Alessandra Cinotti, Giacomo Colletti   +6 more
wiley   +1 more source

Signal mining and analysis of adverse events of Brentuximab Vedotin base on FAERS and JADER databases.

PLoS ONE
ObjectivesBrentuximab Vedotin (BV) is a novel antibody-drug conjugate (ADC) approved for the treatment of classical Hodgkin's lymphoma and systemic anaplastic large cell lymphoma.
Feilong Tan, Yanhua Li, Hongying Xia, Wenjie Yin   +3 more
doaj   +1 more source

Morphological Description of Three Rare Canine Intraocular Tumours

, 2010
Introduction Tumours of glial and neuroepithelial origin (except for iridociliary adenomas) are rare intraocular neoplasms in dogs. Morphological and immunohistochemical features of three intraocular neoplasms are presented and categorized according to ...
J. Brandes, J.P. Teifke, Brandes, J., Teifke, Jens Peter   +3 more
core   +1 more source

A case report: Diagnosis and treatment of idiopathic hypertrophic pachymeningitis

Ibrain, Volume 11, Issue 1, Page 112-116, Spring 2025.
We reported a case of idiopathic hypertrophic dura meningitis diagnosed in our hospital. The patient repeatedly suffered from headaches, followed by blurred vision in the right eye. During this period, multiple sclerosis was considered for diagnosis, and it improved after hormone treatment.
Zhong Luo, Piao Cao, Jing‐Qing Xu, Rong Yan, Jian Wang, Tao Liang, Ya Chen, Zu‐Cai Xu   +7 more
wiley   +1 more source