Results 121 to 130 of about 614,157 (313)

Organoid‐tissue extracellular vesicles

Interdisciplinary Medicine, EarlyView.
Abstract Extracellular vesicles (EVs) are lipid bilayer structures secreted by cells that act as intercellular messengers. Tissue‐derived EVs (TEVs), harvested from the tissue interstitium, directly reflect the actual physiological or pathological state of the tissue microenvironment.
Han Liu, Ting Cheng, Guangfeng Li, Zhidao Xia, Chenglong Wang, Ke Xu, Jiacan Su   +6 more
wiley   +1 more source

Generative artificial intelligence in medical imaging: Current landscape, challenges, and future directions

Interdisciplinary Medicine, EarlyView.
This review explores the applications of Generative AI (GAI) in medical imaging, with emphasis on its potential to enhance AI training and personalized medicine. The study comprehensively examines frameworks for evaluating the validity of GAI‐generated images while identifying critical challenges including model bias, data augmentation reliability, and
Wenle He, Xuewei Wu, Zhe Jin, Jie Sun, Xiaofeng Jiang, Shuixing Zhang, Bin Zhang   +6 more
wiley   +1 more source

Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects

Interdisciplinary Medicine, EarlyView.
The effects of clinical therapies for spinal cord injury (SCI) are greatly limited due to poor axon regeneration. This review systematically discusses the ability of nanomaterials (NMs) to treat SCI and the mechanism underlying their therapeutic effects. The properties of NMs that are conducive to axon regeneration after SCI are outlined.
Jia Liu, Zhendong Huang, Xiner Tan, Wei Du, Ziyang Wang, Xinru Zhou, Hao Pan, Lili Chen, Yiyuan Kang, Longquan Shao   +9 more
wiley   +1 more source

Fluorescence Lifetime Imaging Techniques—A Review on Principles, Applications and Clinical Relevance

Journal of Biophotonics, EarlyView.
This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities and typical applications in biology and clinical studies. ABSTRACT This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities, and typical applications ...
V. I. Shcheslavskiy, M. V. Shirmanova, K. S. Yashin, A. C. Rück, M. C. Skala, W. Becker   +5 more
wiley   +1 more source

Shining a Light on the Future of Biophotonics

Journal of Biophotonics, EarlyView.
ABSTRACT Biophotonics—the interdisciplinary fusion of light‐based technologies with biology and medicine—is rapidly transforming research, diagnostics, and therapy across various domains. This white paper, developed in conjunction with the International Congress on Biophotonics 2024, offers a comprehensive overview of the current landscape and future ...
Francesco Baldini, Kishan Dholakia, Paul French, Orlando Guntinas‐Lichius, Achim Kohler, Werner Mäntele, Laura Marcu, Ronald Sroka, Siva Umapathy, Juergen Popp   +9 more
wiley   +1 more source

Indication‐Specific Dosing and Dose‐Evaluation Strategies in New Indications for Non‐Oncology Monoclonal Antibodies

The Journal of Clinical Pharmacology, EarlyView.
Abstract Compared to traditional small molecule drugs, monoclonal antibodies (mAbs) often display more complex pharmacokinetic (PK) and pharmacodynamic (PD) properties that may be impacted by disease‐specific factors. For mAbs in non‐oncology indications, where the same drug might be used for conditions involving different organ systems and/or having ...
Sherouk M. Tawfik, Fei Tang
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Deconvolution Techniques in Optical Coherence Tomography: Advancements, Challenges, and Future Prospects

Laser &Photonics Reviews, EarlyView.
This review explores deconvolution techniques in optical coherence tomography (OCT), addressing resolution degradation from point‐spread functions (PSF). It reviews foundational principles (e.g., Richardson‐Lucy deconvolution) to advanced AI‐driven methods, emphasizing clinical translation and interdisciplinary collaboration. Real‐world implementations
Syeda Aimen Abbasi, Di Mei, Yuanyuan Wei, Chao Xu, Syed Muhammad Tariq Abbasi, Sadia Shakil, Wu Yuan   +6 more
wiley   +1 more source

Innovative Thermosensitive Composite Materials: Merging Poloxamer PF‐127 and Polysaccharides for Enhanced Functional Properties

Macromolecular Materials and Engineering, EarlyView.
The poloxamer Pluronic‐F‐127‐based hydrogels are improved by the implementation of polysaccharides with different concentration ranges and structural organizations. The interactions between the polysaccharide structures and the poloxamer micellar aggregation confer the system better rheological properties and longer drug release times explained by ...
Marcos Blanco‐López, Inmaculada de Dios‐Pérez, Álvaro González‐Garcinuño, Antonio Tabernero, Eva Martín del Valle   +4 more
wiley   +1 more source

Advances and Challenges in Pluripotent Stem Cell‐Based Whole‐Cell Vaccines for Cancer Treatment

Medicine Bulletin, EarlyView.
ABSTRACT In recent decades, an unexpected application of pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), as a novel source for whole‐cell vaccines (WCVs) against cancer has attracted attention in the field of tumor immunotherapy.
Guoyue Wan, Jian‐Dong Huang, Ren‐He Xu, Meiling Jin   +3 more
wiley   +1 more source