Results 131 to 140 of about 614,157 (313)

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Intestinal and extraintestinal manifestations in familial adenomatous polyposis [PDF]

Vojnosanitetski Pregled, 2007
Nagorni Aleksandar, Bjelaković Goran, Katić Vuka, Veselinović Dragan   +3 more
doaj   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, EarlyView.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular‐Related Complications

Molecular Nutrition &Food Research, EarlyView.
(Poly)phenols constitute a source of natural therapeutic molecules capable of targeting angiogenesis in different scenarios. This review summarizes the current evidence of the role of (poly)phenols in modulating angiogenesis. The reader can find a compilation of preclinical and human investigations describing pro‐ and anti‐angiogenic effects of these ...
María Ángeles Ávila‐Gálvez, Antonio Vico‐Padilla, Claus Schneider, Juan Carlos Espín, Antonio González‐Sarrías, Juan Antonio Giménez‐Bastida   +5 more
wiley   +1 more source

Anti‐Inflammatory/Antioxidant Features of Adipose Tissue Mesenchymal Stem Cells Conditioned Media for Doped TiO2 Nanoparticles in Induced Inflammation

ChemistryOpen, EarlyView.
The PI3K/AKT pathway is triggered when lipopolysaccharide (LPS) binds to TLR4 on the cell membrane. This causes the NF‐κB complex to get phosphorylated and IKB to degrade, allowing NF‐κB to go into the nucleus. Pro‐inflammatory genes including interleukin‐4 (IL‐4), IL‐6, and tumor necrosis factor α are triggered by this.
Ahmed A. Abd‐Rabou, Ahmed M. Youssef, Mohamed I. El‐Khonezy, Soheir E. Kotob, Mohamed S. Kishta   +4 more
wiley   +1 more source

Anemia and retinopathy of prematurity: A narrative review

Pediatric Investigation, EarlyView.
Anemia in infants who are at greatest risk of developing severe retinopathy of prematurity is almost universal. There is plausible evidence in the literature correlating anemia with severe ROP. However, the relationship is complex, and further study is needed to better understand the potential molecular mechanisms for anemia‐associated ROP.
Minali Prasad, David Dombrovsky, Stephen P. Christiansen, Ellen C. Ingolfsland   +3 more
wiley   +1 more source

Retinoma: An overview

Pediatric Investigation, EarlyView.
Retinoma, a benign tumor caused by biallelic retinoblastoma gene (RB1) inactivation, offers key insights into retinoblastoma development and oncogenesis. This review explores its molecular genetics, clinical features, diagnosis, management, and potential implications for advancing the prevention and treatment of retinoblastoma.
Panagiotis N. Toumasis, Ashwin Mallipatna, Timothy W. Corson, Helen Dimaras   +3 more
wiley   +1 more source

Ocular involvement in newly diagnosed pediatric leukemia: A systematic review and meta‐analysis

Pediatric Investigation, EarlyView.
The global prevalence of ocular involvement in pediatric leukemia is estimated to be 20.32%, which is more common than previously recognized. Given the high rate of asymptomatic involvement, screening for all newly diagnosed leukemia patients is recommended.
Kristina Nazzicone, Rachel Kim, Alexa Fine, Aidan Pucchio, Laura Wheaton, Christine Law   +5 more
wiley   +1 more source

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

PROTEOMICS, EarlyView.
ABSTRACT Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications.
De‐Wei An, Dries S. Martens, Gontse G. Mokwatsi, Yu‐Ling Yu, Babangida S. Chori, Agnieszka Latosinska, Godsent Isiguzo, Susanne Eder, Dong‐Yan Zhang, Gert Mayer, Ruan Kruger, Jana Brguljan‐Hitij, Christian Delles, Catharina M. C. Mels, Katarzyna Stolarz‐Skrzypek, Marek Rajzer, Peter Verhamme, Aletta E. Schutte, Tim S. Nawrot, Yan Li, Harald Mischak, Augustine N. Odili, Jan A. Staessen   +22 more
wiley   +1 more source