Results 201 to 210 of about 91,701 (297)

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, Volume 22, Issue 27, 14 May 2026.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source

Benign foveal retinal pigment epithelium hypopigmentation without functional loss : pediatric case series. [PDF]

Graefes Arch Clin Exp Ophthalmol
Boulert E, Drumare I, Dhaenens CM, Defoort-Dhellemmes S, Smirnov V.   +4 more
europepmc   +1 more source

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration. [PDF]

Nat Commun
Li S, Liu H, Pan SH, Zhu Z, Zhang S, Li J, Yao Y, Wang X, Gao N, Liu X, Chen M, Hu H, Pan W, Zhu Q, Cai Y, Qu J, Gao S, Su J.   +17 more
europepmc   +1 more source

Morphological and Imaging Characterization of the Eye and Adnexa of the Lesser Anteater (Tamandua tetradactyla)

Anatomia, Histologia, Embryologia, Volume 55, Issue 3, May 2026.
ABSTRACT The southern tamandua (Tamandua tetradactyla) is a species vulnerable to environmental disturbances, largely due to increasing overlap between its natural habitat and anthropogenically modified landscapes. Detailed anatomical knowledge of the eye and orbital structures, supported by imaging and histological analyses, is essential to improve ...
Estela Larissa Silva dos Santos, Amanda Vieira Fernandes, Francisco de Assis Dórea Neto, Caterina Muramoto, Danielle Nascimento Silva, Ana Cláudia Raposo, Marcia Maria Dantas de Faria, Ricardo Diniz Guerra e Silva, Alessandra Estrela Lima, Érica Augusta dos Anjos Cerqueira da Silva, Arianne Pontes Oriá   +10 more
wiley   +1 more source

Phagocytosis by retinal pigment epithelium and microglia does not affect vision restoration by P3HT nanoparticles in Retinitis pigmentosa. [PDF]

Cell Death Dis
Mantero G, Francia S, Galluzzi F, Telitsyn N, Shmal D, Cupini S, Porzano E, Perna A, Vincenzi M, Ribeiro JF, Berdondini L, Lanzani G, Pertile G, Di Marco S, Benfenati F, Colombo E.   +15 more
europepmc   +1 more source

Choroidal vascular hyperpermeability patterns in central serous chorioretinopathy correlate with microperimetry: CERTAIN study report 4

Acta Ophthalmologica, Volume 104, Issue 3, Page 288-295, May 2026.
Abstract Purpose This report evaluates the association of three distinct leakage patterns of choroidal vascular hyperpermeability (CVH) on indocyanine green angiography (ICGA), previously correlated with disease chronicity, with retinal sensitivity measured by microperimetry in central serous chorioretinopathy (CSC): unifocal indistinct signs of ...
Jennifer M. Chang‐Wolf, Laurenz J. B. Pauleikhoff, Chabelie Ruiters, Annette C. Moll, Reinier O. Schlingemann, Elon H. C. van Dijk, Roselie M. H. Diederen, Camiel J. F. Boon   +7 more
wiley   +1 more source

Specialised features of melanosomes in health and disease in the retinal pigment epithelium. [PDF]

Front Cell Dev Biol
Doncheva D, Eden ER, Futter CE.
europepmc   +1 more source

Real‐world outcomes of aflibercept 8 mg in patients previously treated for neovascular age‐related macular degeneration

Acta Ophthalmologica, Volume 104, Issue 3, Page 296-304, May 2026.
Abstract Purpose To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age‐related macular degeneration (nAMD). Methods This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti‐VEGF therapies at Sahlgrenska University Hospital between February 2024 and ...
Imadeddin Abu Ishkheidem, Esra Inci, Martin Breimer, Sofia Töyrä Silfverswärd, Madeleine Zetterberg, Marita Andersson Grönlund   +5 more
wiley   +1 more source