Results 181 to 190 of about 91,701 (297)

Caffeine Alleviates Oxidative Damage of Retinal Pigment Epithelium Cells. [PDF]

J Ophthalmol
Liu H, Zhang W, Xiong Y, Yang M, Long H, Gong C, Li S.   +6 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Cell loss disrupts mechanical homeostasis to drive retinal pigment epithelium ageing-like phenotype in vitro. [PDF]

Nat Commun
Piskova T, Kozyrina AN, Astrauskaitė G, Mabrouk ME, Schepl S, Yam SLS, Ravithas R, Wagner W, Vassalli M, Di Russo J.   +9 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Concentric retinal pigment epithelium tear in central serous chorioretinopathy

Indian Journal of Ophthalmology, 2019
Darshana Daga, Vinod Kumar, Shorya V Azad   +2 more
doaj   +1 more source

Histologic Photoreceptor and Retinal Pigment Epithelium Degeneration in an Eye With Clinically Documented Geographic Atrophy of AMD. [PDF]

Invest Ophthalmol Vis Sci
Curcio CA, Messinger JD, Sloan KR, Edwards MM, Bijon J, Huemer F, Leingang O, Freund KB, Berlin A.   +8 more
europepmc   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Changes in macular structure after removal of epiretinal membrane in combined hamartomas of the retina and retinal pigment epithelium. [PDF]

Sci Rep
Lee CH, Kim KH, Choi YJ, Yang JM, Lee SM, Choi EY, Lee J, Kim M.   +7 more
europepmc   +1 more source

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Splicing variants in MYRF cause partial loss of function in the retinal pigment epithelium leading to nanophthalmos. [PDF]

JCI Insight
Rozumek GM, Brinkmeier ML, Guan B, Wang SQ, Tower C, Yang NT, Lim RS, Kong D, Soden D, Zhang Q, Han JY, Miller JM, Dong L, Hannum DF, Moroi SE, Richards JE, Hufnagel RB, Prasov L.   +17 more
europepmc   +1 more source