Results 21 to 30 of about 56,253 (246)

Long term evolution of combined hamartoma of the retina and retinal pigment epithelium

Vision Pan-America, 2014
Combined hamartoma of the retina and of the retinal pigment epithelium are extremely rare benign tumors distinguished by retinal pigment epithelium (RPE) and glial tissue proliferation, provoking severe peripapillary and retinal distortion ...
Miriam García Fernández, Joaquín Castro Navarro   +1 more
doaj   +1 more source

Retinal pigment epithelium changes in Kartagener syndrome

American Journal of Ophthalmology Case Reports, 2018
Purpose: We present the first case in the literature of a patient with Kartagener syndrome and ocular findings of nonexudative age-related macular degeneration. Observations: A 55-year-old woman with Kartagener syndrome and chronic angle closure glaucoma
Maria D. Garcia, Camila V. Ventura, João R. Dias, Ta Chen P. Chang, Audina M. Berrocal   +4 more
doaj   +1 more source

A Single-Cell Transcriptome Atlas of the Human Retinal Pigment Epithelium

Frontiers in Cell and Developmental Biology, 2021
Human retinal pigment epithelium cells are arranged in a monolayer that plays an important supporting role in the retina. Although the heterogeneity of specific retinal cells has been well studied, the diversity of hRPE cells has not been reported. Here,
Zongren Xu, Zongren Xu, Zongren Xu, Zongren Xu, Xingyun Liao, Xingyun Liao, Xingyun Liao, Xingyun Liao, Na Li, Hongxiu Zhou, Hongxiu Zhou, Hongxiu Zhou, Hong Li, Hong Li, Hong Li, Qi Zhang, Qi Zhang, Qi Zhang, Ke Hu, Ke Hu, Ke Hu, Peizeng Yang, Peizeng Yang, Peizeng Yang, Peizeng Yang, Shengping Hou, Shengping Hou, Shengping Hou, Shengping Hou   +28 more
doaj   +1 more source

Advances in the study of tissue-engineered retinal pigment epithelial cell sheets

Regenerative Therapy
Regarded as the most promising treatment modality for retinal degenerative diseases, retinal pigment epithelium cell replacement therapy holds significant potential.
Wang Zhou, Yujiao Chai, Shan Lu, Qiaohui Yang, Liying Tang, Di Zhou   +5 more
doaj   +1 more source

Familial grouped pigmentation of the retinal pigment epithelium. [PDF]

British Journal of Ophthalmology, 1988
Grouped pigmentation of the retinal pigment epithelium was found in a father and his son. They had a normal resting potential on the electro-oculogram, but the son had a lower normal light rise. We believe this is the first description of familial grouped pigmentation.
de Jong, P.T.V.M., Delleman, J.W.
openaire   +3 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Multifunctional Catechol‐Functionalized Cellulose Hydrogels for the Minimally Invasive Treatment of Acute Optic Nerve Injuries

Advanced Healthcare Materials, EarlyView.
Catechol‐functionalized cellulose hydrogels are developed as injectable, bioadhesive platforms for retinal neuroprotection. The hydrogels exhibit tunable rheological and mechanical properties, strong tissue adhesion, and sustained antioxidative activity.
Kai‐Hsiang Chang, Yi‐Ke Lin, Wei‐Li Chen, Ta‐Ching Chen, Jiashing Yu   +4 more
wiley   +1 more source

The Effects of Anti-Vascular Endothelial Growth Factor Drugs on Retinal Pigment Epithelial Cell Culture

Türk Oftalmoloji Dergisi, 2018
Objectives:To assess the effects of anti-vascular endothelial growth factor (VEGF) drugs on retinal pigment epithelium cell culture.Materials and Methods:Aflibercept (0.5 mg/mL), bevacizumab (0.3125 mg/mL), and ranibizumab (0.125 mg/mL) were applied to ...
Mustafa Şahiner, Dilek Bahar, Ayşe Öner, Zeynep Burçin Gönen, Metin Ünlü, Duygu Gülmez Sevim, Çağatay Karaca, Galip Ertuğrul Mirza   +7 more
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source