Results 91 to 100 of about 93,615 (295)
Frontiers in Oncology, 2019 Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
S. Rajasekaran +12 more
semanticscholar +1 more source
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Acta Ophthalmologica, EarlyView.Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs +12 more
wiley +1 more source
Tumour progression shows decrease in PD‐L1 expression in matched metastases/primary uveal melanomas
Acta Ophthalmologica, EarlyView.Abstract Purpose Immune checkpoint inhibitors (ICI) have revolutionised the treatment of several malignancies. However, the results of ICI therapy remain unsatisfactory in metastatic uveal melanoma (UM). We analysed the expression of PD1, PD‐L1, T‐cell and macrophage markers in a set of matched primary and metastatic UM in an attempt to better ...
Maria Chiara Gelmi +5 more
wiley +1 more source
Synergistic potential of CDK4/6 inhibitors and ATRA in non‐APL AML
British Journal of Haematology, EarlyView.Summary Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by diverse genetic abnormalities. The standard of care remains to be chemotherapy and stem cell transplantation. In acute promyelocytic leukaemia (APL), differentiation therapy with all‐trans retinoic acid (ATRA) has significantly improved outcomes. Despite this, the success
Rafał Skopek +15 more
wiley +1 more source
Journal of Ophthalmology, 2020 Purpose. To investigate the clinical presentations and outcomes of retinoblastoma in relation to the advent of new multimodal treatments in Thailand. Patients and Methods. Retrospective case series.
Duangnate Rojanaporn +9 more
doaj +1 more source
ACVR1C/SMAD2 signaling promotes invasion and growth in retinoblastoma
Oncogene, 2018 Retinoblastoma is the most common intraocular cancer in children. While the primary tumor can often be treated by local or systemic chemotherapy, metastatic dissemination is generally resistant to therapy and remains a leading cause of pediatric cancer ...
L. Asnaghi +15 more
semanticscholar +1 more source
The Role of Histone Methyltransferase SETDB1 in Normal and Malignant Hematopoiesis
Cancer Science, EarlyView.In this review, we discuss the role of SETDB1 in gene regulation, including an overview of its structural features and key cofactors. We also highlight the lineage‐specific roles of SETDB1 in both normal hematopoietic processes and hematological malignancies, emphasizing its function as an immune checkpoint molecule that suppresses natural killer cell ...
Yu‐Hsuan Chang, Susumu Goyama
wiley +1 more source
LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma
Bioscience Reports, 2018 The actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) has been found to serve as an oncogenic long noncoding RNA (lncRNA) in most types of human cancer. The role of AFAP1-AS1 in retinoblastoma remains unknown.
F. Hao +4 more
semanticscholar +1 more source
Aurora‐A Promotes Cell‐Cycle Progression From Quiescence Through Primary Cilia Disassembly
Cancer Science, EarlyView.Our findings demonstrate that AurA facilitates cell cycle reentry by promoting primary cilia disassembly. Utilizing an inducible degron system, we showed that AurA depletion delays the G0/G1 transition, a defect rescued by forced deciliation. These results underscore AurA's role beyond mitosis and reinforce its potential as a therapeutic target in ...
Atsushi Kohso +6 more
wiley +1 more source