Results 91 to 100 of about 145,462 (345)

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer [PDF]

, 2015
Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with
Ertel, Adam, FORTINA, PAOLO, Franco, Jorge, Kathleen McClendon, A., Knudsen, Erik S, Witkiewicz, Agnieszka K.   +5 more
core   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Case Series on Imaging Features of Trilateral and Quadrilateral Retinoblastoma: What Radiologists Need to Know

International Journal of Integrated Health Sciences
Objective: To identify the differences between trilateral and quadrilateral retinoblastoma based on radiologic imaging. Case: We found three cases of retinoblastoma at Sanglah General Hospital.
Fiona Fiona, Pande Putu Yuli Anandasari, Ni Nyoman Margiani   +2 more
doaj   +1 more source

Patient knowledge, experiences and preferences regarding retinoblastoma and research: A qualitative study

Health Expectations, 2020
Background We launched a patient engagement strategy to facilitate research involvement of the retinoblastoma (childhood eye cancer) community in Canada.
Catherine Moses, Kaitlyn Flegg, Helen Dimaras   +2 more
doaj   +1 more source

Secondary acute myeloid leukemia in a child treated for retinoblastoma: A case report with review of literature

Journal of Family Medicine and Primary Care, 2020
The most devastating late adverse effect of childhood cancer treatment is development of second malignancies. Retinoblastoma is the most common ocular malignancy of childhood and has a very good cure rate.
Latha M Sneha, John Arockia, Febi Renjitha Suman, Vikas Khethan   +3 more
doaj   +1 more source

A Feedback Loop of LINC00665 and the Wnt Signaling Pathway Expedites Osteosarcoma Cell Proliferation, Invasion, and Epithelial‐Mesenchymal Transition

Orthopaedic Surgery, Volume 15, Issue 1, Page 286-300, January 2023., 2023
TCF/LEF transcription complex induced the up‐regulation of LINC00665 and LINC00665 promoted OS cell growth. Mechanistically, LINC00665 functioned as a ceRNA to modulate miR‐1249‐5p and thereby up‐regulate WNT2B to enhance the Wnt pathway and the expression of downstream genes, which formed a positive feedback loop.
Jinyu Bai, Xiao Zhang, Fengxian Jiang, Huajian Shan, Xiang Gao, Lin Bo, Yingzi Zhang   +6 more
wiley   +1 more source

A novel retinoblastoma therapy from genomic and epigenetic analyses. [PDF]

, 2012
Retinoblastoma is an aggressive childhood cancer of the developing retina that is initiated by the biallelic loss of RB1. Tumours progress very quickly following RB1 inactivation but the underlying mechanism is not known.
Bahrami, Armita, Benavente, Claudia A, Brennan, Rachel, Chen, Xiang, Ding, Li, Dooling, David J, Downing, James R, Dyer, Michael A, Dyson, Nicholas J, Easton, John, Ellison, David, Flores-Otero, Jacqueline, Fulton, Lucinda L, Fulton, Robert S, Gupta, Pankaj, Hong, Xin, Lu, Charles, Ma, Jing, Manning, Amity L, Mardis, Elaine R, McEvoy, Justina, Mukatira, Suraj, Mullighan, Charles, Naeve, Clayton, Neale, Geoff, Ochoa, Kerri, Pounds, Stanley, Rusch, Michael, Shurtleff, Sheila, Ulyanov, Anatoly, Wang, Jianmin, Wilson, Matthew, Wilson, Richard K, Wu, Gang, Zhang, Jinghui, Zhao, David   +35 more
core  

Cuproplasia and cuproptosis, two sides of the coin

Cancer Communications, EarlyView.
Abstract Copper is an essential micronutrient in the human body, mainly acting as a crucial cofactor required for a wide range of physiological processes across nearly all cell types. Recent advances revealed that tumor cells seize copper to fulfill their rapid proliferation, metastasis, immune evasion, and so on by reprogramming the copper regulatory ...
Kaizhong Lu, Chandra Sugiarto Wijaya, Qinghua Yao, Hongchuan Jin, Lifeng Feng   +4 more
wiley   +1 more source

Evaluation of KI-67, Apoptosis, and Hyaluronic Acid in Grading Retinoblastoma

Folia Medica Indonesiana, 2019
Hyaluronic acid (HA) is a glycosaminoglycan with a straight-chain polymer arrangement defined as the extracellular matrix constituent. High molecular weight HA has normal physicochemical, biological, and physiological properties whereas low molecular ...
Hendrian D Soebagjo, Nurwasis Nurwasis, Ugresone Y Bintoro, Sutiman B Soemitro   +3 more
doaj   +1 more source

Forced Trefoil Factor Family Peptide 3 (TFF3) Expression Reduces Growth, Viability, and Tumorigenicity of Human Retinoblastoma Cell Lines. [PDF]

PLoS ONE, 2016
Trefoil factor family (TFF) peptides have been shown to effect cell proliferation, apoptosis, migration and invasion of normal cells and various cancer cell lines.
Jan Große-Kreul, Maike Busch, Claudia Winter, Stefanie Pikos, Harald Stephan, Nicole Dünker   +5 more
doaj   +1 more source