Results 141 to 150 of about 66,792 (243)

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Consideraciones clínicas, diagnósticas y de tratamiento en retinoblastoma [PDF]

, 2011
El retinoblastoma es el tumor intraocular primario más frecuente en la infancia. Su detección temprana y el inicio del tratamiento adecuado permiten mejorar dramáticamente la sobrevida en estos niños. En este artículo se hace una revisión general de
Ivonne Andrea Moreno Martínez, Ronald Andrés Serrano Uribe, Quintero Pérez, Lina María, Serrano Uribe, Ronald Andrés, Moreno Martínez, Ivonne Andrea, John Fredy Villamil Duarte, Villamil Duarte, John Fredy, Lina María Quintero Pérez   +7 more
core   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, Volume 59, Issue 7, July 2026.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin, Yuhan Zhang, Yuantai Zhu, Zhiyuan Zhang, Chaoji Shi   +4 more
wiley   +1 more source

A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley   +1 more source

Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status

International Journal of Cancer, Volume 158, Issue 12, Page 3268-3278, 15 June 2026.
What's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Klaus W. Fagerstedt, Sami Kilpinen, Johanna Arola, Benjamin Z. Sundqvist, Tom Böhling, Leif C. Andersson, Harri Sihto   +6 more
wiley   +1 more source

Trilateral retinoblastoma [PDF]

, 2011
Trilateral retinoblastoma is the association of hereditary bilateral or unilateral retinoblastoma with a pineal neuroblastic tumour. We describe two cases of trilateral retinoblastoma from a total of 141 cases of retinoblastoma seen over an 8.5 year ...
Tuan Norhafizah binti Tuan Zakaria
core  

GENETIC PROFILE OF RETINOBLASTOMA PATIENTS FROM A REFERRAL HOSPITAL IN GUJARAT

National Journal of Medical Research, 2012
 Background & objectives: Retinoblastoma is the most common intraocular malignancy of infant and childhood. It is the first disease for which a genetic etiology of cancer has been described and the first suppressor gene identified.
Sunil G Oza, Brijesh M Patel , Niyati R Parikh, Sweta B Prajapati, Hrishikesh R Jadav, Pensi C A   +5 more
doaj  

An analysis of pediatric retinoblastoma medical malpractice litigation. [PDF]

PLoS One
Miller V, Reese AD, Foote K, Navarro A, Galfano A, Hietanen C.   +5 more
europepmc   +1 more source

Orbital Fungating Mass as a Rare Manifestation of Retinoblastoma: A Case Study in Palliative Care. [PDF]

Am J Case Rep
Susanty A, Maliani K, Kartiwa A, Cahyadi D, Utami P, Kristina Y, Leoni ND, Pemberiadi DM.   +7 more
europepmc   +1 more source