Results 171 to 180 of about 151,276 (329)

Socioeconomic background and childhood cancer survival in Germany: A nationwide assessment based on data from the German Childhood Cancer Registry

open access: yesInternational Journal of Cancer, Volume 157, Issue 11, Page 2235-2247, 1 December 2025.
What's New? Significant advances in childhood cancer survival have transformed outcomes for many children globally. However, emerging evidence suggests that, even in settings with universal healthcare, these gains are not equally distributed. Here, the authors focused on childhood cancer survival in Germany, using data from the German Childhood Cancer ...
Maike Wellbrock   +7 more
wiley   +1 more source

Managing and treating intraocular retinoblastoma

open access: yesCommunity Eye Health Journal, 2018
In order to improve the survival rates of children with retinoblastoma, a collaborative and multidisciplinary approach is essential, as is a listening ear for parents who may struggle with the difficult decisions facing ...
Ashwin Reddy, Mukesh Jain, Vikas Khetan
doaj  

Hold Me Tight Group Intervention for Parents of Children With Cancer

open access: yesJournal of Family Therapy, Volume 47, Issue 4, November 2025.
ABSTRACT This present article reports on the experiences of parents of children with cancer who participated in an emotionally focused Hold Me Tight (HMT) group intervention. A purposive sample of 24 parents was recruited from 3‐day HMT courses. Focus group conversations were conducted at the end of each course and analysed using Interpretative ...
Krista Koivula   +5 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

open access: yesActa Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs   +12 more
wiley   +1 more source

Novel Pyrazolo [1,5‐a]−1,3,5‐Triazine Derivatives as CDK7 Inhibitors: Synthesis and Biological Insights in Pancreatic Ductal Adenocarcinoma Models

open access: yesChemMedChem, Volume 20, Issue 19, October 6, 2025.
Pyrazolo [1,5‐a]−1,3,5‐triazine derivatives efficiently synthesized showed remarkable cytotoxicity and inhibition of cell migration in PDAC models. They induced apoptosis, upregulated apoptotic gene expression, and disrupted the cell cycle, significantly reducing the viability of spheroidal PATU‐T cultures.
Daniela Carbone   +10 more
wiley   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

open access: yesAdvanced Biology, Volume 9, Issue 10, October 2025.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez   +3 more
wiley   +1 more source

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