Results 171 to 180 of about 145,462 (345)

Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Immune checkpoint inhibitors, such as anti­PD1, revolutionized melanoma treatment. However, resistance and low response rates remain problems. Our goal was to pinpoint actionable biomarkers of resistance to anti‐PD1 treatment and verify therapeutic effectiveness in vivo.
Szonja Anna Kovács, Tamás Kovács, András Lánczky, Ágnes Paál, Zsombor I. Hegedűs, Nabil V. Sayour, Lilla Szabó, Andrea Kovács, Giampaolo Bianchini, Péter Ferdinandy, Alberto Ocana, Zoltán V. Varga, János Tibor Fekete, Balázs Győrffy   +13 more
wiley   +1 more source

Retinoblastoma. Report on 19 patients treated with radio- therapy. [PDF]

, 1965
Mark Paterson, Alexander A. Charteris
openalex   +1 more source

Geographical Discrepancy in Medical Care Access Among Children, Adolescents, and Young Adults With Cancer in Japan, 2016–2019

Cancer Science, EarlyView.
Using nationwide cancer registry data (n = 99,968), we analyzed geographical disparities in access to cancer care among patients aged 0–39 years in Japan between 2016 and 2019. While most patients received treatment within their residential prefecture, significant variations were observed, particularly among retinoblastoma patients and those both in ...
Anna Tsutsui, Yoshitaka Murakami, Takako Fujimaki, Masayuki Endo, Yuko Ohno   +4 more
wiley   +1 more source

DIFFUSE INFILTRATING RETINOBLASTOMA [PDF]

, 1960
P. B. Schofield
openalex   +1 more source

Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patients

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race of origin in a global cohort of patients. Methods Retrospective collaborative study of 1426 patients who underwent primary enucleation for retinoblastoma. Results Patients were grouped into Caucasians (n = 231, 16%), Asians (
Swathi Kaliki, Vijitha S. Vempuluru, Alia Ahmad, Jesse L. Berry, Rosdali Diaz‐Coronado, Maya Eiger‐Moscovich, Ido Didi Fabian, Hans Grossniklaus, G. Baker Hubbard III, Mona Mohammad, Jacob Pe'er, M. Ashwin Reddy, Mandeep S. Sagoo, Carol L. Shields, Sandra E. Staffieri, Mika Tanabe, Tatiana Ushakova, Yacoub A. Yousef, High‐Risk Retinoblastoma Collaborative Study Group, Jacob Pe’er, Mandeep S. Sagoo   +20 more
wiley   +1 more source

Large interstitial del(13)(q13q14.3): the importance of detailed clinical information in cytogenetic studies [PDF]

, 2011
Interstitial deletions of chromosome 13 are known to be associated with retinoblastoma. A wider syndrome may accompany the deletion, including mental retardation and craniofacial dysmorphism.
Correia, Hildeberto, Fonseca Silva, Maria da Luz, Margarida, Azevedo, Mota Freitas, Manuela, Oliva Teles, Natália, Oliveira, Fernanda Paula, Ribeiro, Joana   +6 more
core  

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Managing and treating intraocular retinoblastoma

Community Eye Health Journal, 2018
In order to improve the survival rates of children with retinoblastoma, a collaborative and multidisciplinary approach is essential, as is a listening ear for parents who may struggle with the difficult decisions facing ...
Ashwin Reddy, Mukesh Jain, Vikas Khetan
doaj  

Epigenetic control of cell identities from epiblast to gastrulation

The FEBS Journal, EarlyView.
In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley   +1 more source

The retinoblastoma protein and cell cycle control

Cell, 1995
R. Weinberg
semanticscholar   +1 more source