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Pediatric Clinics of North America, 2013
Retinoblastoma is the most common neoplasm of the eye in childhood, and represents 3% of all childhood malignancies. Retinoblastoma is a cancer of the very young; two-thirds are diagnosed before 2 years of age and 95% before 5 years. Retinoblastoma presents in 2 distinct clinical forms: (1) a bilateral or multifocal, heritable form (25% of all cases ...
Carlos, Rodriguez-Galindo +2 more
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Retinoblastoma is the most common neoplasm of the eye in childhood, and represents 3% of all childhood malignancies. Retinoblastoma is a cancer of the very young; two-thirds are diagnosed before 2 years of age and 95% before 5 years. Retinoblastoma presents in 2 distinct clinical forms: (1) a bilateral or multifocal, heritable form (25% of all cases ...
Carlos, Rodriguez-Galindo +2 more
openaire +4 more sources
The Indian Journal of Pediatrics, 2016
Retinoblastoma represents 3% of all childhood cancers, and is the most common intraocular malignancy of childhood. It is fatal, if untreated. White eye reflex, also known as leukocoria, is the commonest sign, followed by strabismus. The pediatricians have a very important role to play in the diagnosis of this relatively rare, but easily detectable ...
Raksha, Rao, Santosh G, Honavar
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Retinoblastoma represents 3% of all childhood cancers, and is the most common intraocular malignancy of childhood. It is fatal, if untreated. White eye reflex, also known as leukocoria, is the commonest sign, followed by strabismus. The pediatricians have a very important role to play in the diagnosis of this relatively rare, but easily detectable ...
Raksha, Rao, Santosh G, Honavar
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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.
Science, 1989Deletions or mutations of the retinoblastoma gene, RB1, are common features of many tumors and tumor cell lines. Recently, the RB1 gene product, p105-RB, has been shown to form stable protein/protein complexes with the oncoproteins of two DNA tumor ...
N. Dyson +3 more
semanticscholar +1 more source
Cancer Nursing, 1991
Retinoblastoma, although a rare childhood cancer, is the most common primary malignant intraocular tumor of infancy and early childhood. In 75% of the cases, retinoblastoma is unilateral, and in 25% of the cases, retinoblastoma is bilateral. Presenting signs and symptoms of retinoblastoma, genetics, diagnostic tests, and their implications are reviewed
C A, Servodidio +2 more
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Retinoblastoma, although a rare childhood cancer, is the most common primary malignant intraocular tumor of infancy and early childhood. In 75% of the cases, retinoblastoma is unilateral, and in 25% of the cases, retinoblastoma is bilateral. Presenting signs and symptoms of retinoblastoma, genetics, diagnostic tests, and their implications are reviewed
C A, Servodidio +2 more
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Intra-arterial chemotherapy for retinoblastoma: an updated systematic review and meta-analysis
Journal of NeuroInterventional Surgery, 2019Background and purpose Intra-arterial chemotherapy for retinoblastoma has been adopted as a first-line treatment option by numerous tertiary centers.
K. Ravindran +3 more
semanticscholar +1 more source
2004
Retinoblastoma (Rb) is a malignant tumor that originates from developing retina. Diagnosis based on clinical signs and symptoms and is usually made in children under the age of five years. Mutations in both alleles of the RB1 gene are a prerequisite for this tumor to develop.
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Retinoblastoma (Rb) is a malignant tumor that originates from developing retina. Diagnosis based on clinical signs and symptoms and is usually made in children under the age of five years. Mutations in both alleles of the RB1 gene are a prerequisite for this tumor to develop.
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Journal of Pediatric Ophthalmology & Strabismus, 1987
ABSTRACT Retinoblastoma was diagnosed in 74 patients between July 1967 and February 1987. Thirty cases (40%) were bilateral; 39 were female and 35 were male. Treatment in bilateral cases consisted of enucleation of the more involved eye and a combined approach of supervoltage irradiation, cryocoagulation, and photocoagulation to the remaining
E M, Helveston, K R, Knuth, F D, Ellis
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ABSTRACT Retinoblastoma was diagnosed in 74 patients between July 1967 and February 1987. Thirty cases (40%) were bilateral; 39 were female and 35 were male. Treatment in bilateral cases consisted of enucleation of the more involved eye and a combined approach of supervoltage irradiation, cryocoagulation, and photocoagulation to the remaining
E M, Helveston, K R, Knuth, F D, Ellis
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Retinoblastoma Incidence Trends in Canada: A National Comprehensive Population-Based Study.
Journal of pediatric ophthalmology and strabismus, 2019PURPOSE To determine the incidence rates and geographic distribution of retinoblastoma in Canada to aid cancer control programs. METHODS Patients with retinoblastoma whose data were available from the Canadian Cancer Registry (CCR) and Le Registre ...
R. Darwich +7 more
semanticscholar +1 more source
Bilateral retinoblastoma with ectopic intracranial retinoblastoma: Trilateral retinoblastoma
Cancer Genetics and Cytogenetics, 1982In 11 patients, bilateral retinoblastoma presented at a mean age of 6 months and pineoblastoma at 4 years. We suggest that the hereditary multicentric retinoblastoma arose in vestigeal photoreceptors in the pineal as well as in the hypothetical retinoblasts of the retina.
Judith L. Bader +6 more
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