Results 81 to 90 of about 57,140 (129)

XPO1 inhibition by selinexor induces potent cytotoxicity against high grade bladder malignancies. [PDF]

, 2018
Treatment options for high grade urothelial cancers are limited and have remained largely unchanged for several decades. Selinexor (KPT-330), a first in class small molecule that inhibits the nuclear export protein XPO1, has shown efficacy as a single ...
Baek, Han Bit, Fernandez-Rubio, Aleida, Gandour-Edwards, Regina, Ghosh, Paramita M, Landesman, Yosef, Libertini, Stephen J, Lombard, Alan P, Mudryj, Maria, Nakagawa, Rachel, Nishida, Kristine, Siddiqui, Salma, Vidallo, Kathleen, Vinall, Ruth, Weiss, Robert H, Wettersten, Hiromi   +14 more
core   +1 more source

Retinoblastoma in Adults: a Case Report and Literature Review

Journal of Ophthalmic & Vision Research, 2014
Purpose: To report a case of adult retinoblastoma with a wrong diagnosis of melanoma. Case report: Herein, we present an adult retinoblastoma case who was misdiagnosed as melanoma in fine-needle aspiration biopsy with intravitreal hemorrhage and later ...
Mehdi Sharifzadeh, Fariba Ghassemi, Fahimeh Asadi Amoli, Elham Rahmanikhah, Seid Zia Tabatabaie   +4 more
doaj   +1 more source

Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. [PDF]

, 2019
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the retinoblastoma protein Rb, which inhibits cell-cycle progression until its inactivation by ...
Cristea, Sandra, Kõivomägi, Mardo, Rubin, Seth M, Sage, Julien, Skotheim, Jan M, Tambo, Carrie S, Topacio, Benjamin R, Xie, Shicong, Zatulovskiy, Evgeny   +8 more
core  

Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma

EJC Paediatric Oncology, 2023
Introduction: Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of retinoblastoma cells is associated with a high mortality.
Yelena Diarra, Christina Brockmeyer, Karen Fischhuber, Isabel Hülsenbeck, Saskia Ting, Madlen Reschke, Tobias Kiefer, Anna Hannbücken, Maren Wagemanns, Leyla Jabbarli, Selma Sirin, Regina Wieland, Gudrun Fleischhack, Johannes H. Schulte, Martin Ebinger, Dietmar Lohmann, Bert Müller, Daniela Süsskind, Christoph Schwab, Ines Brecht, Angelika Eggert, Stefan Schönberger, Petra Ritter-Sovinz, Nikolaos Bechrakis, Sophia Göricke, Beate Timmermann, Eva Biewald, Petra Ketteler   +27 more
doaj  

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Cell Reports, 2023
Summary: Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses ...
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio   +10 more
doaj  

Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. [PDF]

, 1996
Viral oncoproteins that inactivate the retinoblastoma tumor suppressor protein (pRb) family both block skeletal muscle differentiation and promote cell cycle progression.
Jacks, T, Lassar, AB, Mulligan, GJ, Novitch, BG   +3 more
core  

Recent Developments in Retinoblastoma

Delhi Journal of Ophthalmology, 2016
Retinoblastoma represents 3% of all childhood cancers, and is the most common intraocular malignancy of childhood. It is fatal if untreated. The management of retinoblastoma has gradually evolved over the past few decades, with an aim to not only ...
Raksha Rao, Santosh G Honavar
doaj   +1 more source

Retinoblastoma [PDF]

The American Journal of Nursing, 1982
Donna L. Wong, Lois Roszkowski Dornan
openaire   +3 more sources

Scleral ectasia stabilization following intra-arterial chemotherapy in an eye with recurrent retinoblastoma

American Journal of Ophthalmology Case Reports, 2023
Purpose: To report a case of recurrent retinoblastoma following transpupillary thermotherapy (TTT) with development of scleral ectasia, as well as their successful treatment with intra-arterial chemotherapy.
Warren Pan, Neeraj Chaudhary, Laura Sedig, Amy Edmonds, Raymond Hutchinson, Hakan Demirci   +5 more
doaj  

Genetics and management of retinoblastoma

Journal of Indian Association of Pediatric Surgeons, 2007
Retinoblastoma is the most common intraocular tumor in childhood. In majority of early stage retinoblastoma, the eyeballs as well as vision can be preserved with chemotherapy and local intraocular therapy with laser or photocoagulation.
Bakhshi Sameer, Bakhshi Radhika
doaj