Results 71 to 80 of about 62,977 (257)

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

, 2015
All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we have analyzed the phenotypes of mice lacking, in spermatogonia, all rexinoid receptors (RXRA, RXRB
Aurore Gely-Pernot (802378), Marius Teletin, Marius Teletin (802380), Nadège Vernet, Vernet, Nadege, Benoit, Gérard, Féret, Betty, Dennefeld, Christine, Mark, Manuel, Norbert B. Ghyselinck (107799), Betty Féret, Mathilde Raverdeau (802379), Christine Dennefeld, Christine Dennefeld (802382), Manuel Mark, Gérard Benoit (265726), Norbert B Ghyselinck, Mathilde Raverdeau, Manuel Mark (107795), Gérard Benoit, Muriel Klopfenstein (107793), Klopfenstein, Muriel, Muriel Klopfenstein, Gely-Pernot, Aurore, Ghyselinck, Norbert B, Betty Féret (802381), Raverdeau, Mathilde, Teletin, Marius, Davidson, Irwin, Nadège Vernet (589562), Aurore Gely-Pernot, Irwin Davidson, Irwin Davidson (518811)   +32 more
core   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

A coordinated phosphorylation cascade initiated by MSK1 directs RAR alpha recruitment to target gene promoters

, 2008
The nuclear retinoic acid (RA) receptor alpha (RARα) is a transcriptional transregulator that controls the expression of specific gene subsets through binding at response elements and dynamic interactions with coregulators, which are coordinated by
Christine Ferry, Hughes de The, Annie Bauer, Vanessa Duong, Cecile Rochette-Egly, Nathalie Bruck, Dominique Vitoux   +6 more
core  

Activation of retinoic acid receptors by dihydroretinoids

Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number of genes. Stereospecific saturation of the C13-C14 double bond of all-transretinol by the enzyme, retinol saturase (RetSat), leads to the production
Domínguez Seoane, Marta, Rodríguez de Lera, Ángel, Lintig, Johannes von, Álvarez Rodríguez, Susana, Golczak, Marcin, Palczewski, Krzysztof, Moise, Alexander R, Álvarez Rodríguez, Maria Rosana, Lobo, Glenn P   +8 more
core   +1 more source

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

Interaction between cellular retinoic acid-binding protein II and histone hypoacetylation in renal cell carcinoma

, 2008
Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation which is controlled by histone deacetylase (HD), the study
Viroj Wiwanitkit, Wiwanitkit, Viroj
core  

Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans [PDF]

, 2001
Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP).
Stockli, J., Handschin, C., Meyer, U. A., Hoffmann, K., Podvinec, M.   +4 more
core  

Neuromodulation: Actions of Dopamine, Retinoic Acid, Nitric Oxide, and Other Substances on Retinal Horizontal Cells

, 2023
Douglas G McMahon,1 John E Dowling2 1Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37235, USA; 2Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USACorrespondence: Douglas G McMahon ...
Dowling JE, McMahon DG
core  

Modeling a Hox Gene Network: Stochastic Simulation with Experimental Perturbation [PDF]

, 2003
The Hox genes show a striking segment specific pattern of expression in a variety of vertebrate embryos, and have been the topic of many experimental analyses.
Kastner, Jason Christopher
core   +1 more source