Results 1 to 10 of about 2,616,742 (302)
Temporally regulated FGFR2-retinoic acid signaling mediates dura mater-suture mesenchyme interactions to prevent craniosynostosis in mice [PDF]
International Journal of Oral ScienceCongenital anomalies often arise during critical developmental time windows, yet the underlying mechanisms remain unclear. Here, we identify a time-specific FGFR2-retinoic acid signaling axis regulating postnatal coronal suture development through dura ...
Lu Gao +7 more
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Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues
Scientific Reports, 2021 Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting adenoma and ...
Francesca Pecori Giraldi +4 more
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Microbial Production of Bioactive Retinoic Acid Using Metabolically Engineered Escherichia coli
Microorganisms, 2021 Microbial production of bioactive retinoids, including retinol and retinyl esters, has been successfully reported. Previously, there are no reports on the microbial biosynthesis of retinoic acid.
Minjae Han, Pyung Cheon Lee
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Journal of Materials Science: Materials in Medicine, 2021 Despite recent advances in the treatment of human colon cancer, the chemotherapeutic efficacy against colon cancer is still unsatisfactory. The complexity in colorectal cancer treatment leads to new research in combination therapy to overcome multidrug ...
Narayan Ture +2 more
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Metabolism of all-trans-retinoic acid by cultured human epidermal keratinocytes
Journal of Lipid Research, 1997 The uptake and metabolism of exogenous all-trans-retinoic acid by human epidermal keratinocytes in submerged culture was examined. Retinoic acid presented to keratinocytes in physiological form bound to albumin was rapidly taken up.
R K Randolph, M Simon
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Frontiers in Cell and Developmental Biology, 2022 Neuroblastoma is a pediatric tumour that accounts for more than 15% of cancer-related deaths in children. High-risk tumours are often difficult to treat, and patients’ survival chances are less than 50%. Retinoic acid treatment is part of the maintenance
Roshna Lawrence Gomez +9 more
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Journal of Lipid Research, 1992 In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in ...
Riaz-ul-Haq, F Chytil
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Journal of Lipid Research, 1985 An assay based on negative ion chemical ionization mass spectrometry has been developed to quantify retinoic acid in plasma or serum. The lower limit of detection is 75 pg (240 fmol); normal values of retinoic acid can be determined on as little as 40 ...
J L Napoli +4 more
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International Journal of Applied and Basic Medical Research, 2017 Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug.
Mondal, Dipankar +2 more
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Haematologica, 2019 Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu +9 more
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