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Retinoic Acid and Its Derivatives in Skin [PDF]
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +8 more
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Activation of Retinoic Acid Receptors by Dihydroretinoids [PDF]
Molecular Pharmacology, 2009 Vitamin A-derived metabolites act as ligands for nuclear receptors controlling the expression of a number of genes. Stereospecific saturation of the C(13)-C(14) double bond of all-trans-retinol by the enzyme, retinol saturase (RetSat), leads to the production of (R)-all-trans-13,14-dihydroretinol.
Moise, Alexander R +8 more
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The role of RARG in solid tumor progression and therapeutic potential [PDF]
Discover OncologyRetinoic acid receptor gamma (RARG), a crucial member of the retinoic acid receptors (RARs) family, encompasses two distinct isoforms, namely RARγ1 and RARγ2. RARG is organized into five functional domains: A/B, C, D, E and F.
Shuyan Guo +4 more
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Retinoic Acid and Retinoid X Receptors
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
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Frontiers in Oncology, 2023 Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia (AML), 95% patients have PML-RARA fusion gene as a result of a reciprocal chromosomal translocation t(15;17)(q22; q21). The retinoic acid receptors (RARs) belong to nuclear
Wenjing Ding +13 more
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Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis
Biomolecules, 2022 Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A.
Qile Deng, Jixiang Chen
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Discover Oncology, 2023 TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong +5 more
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Retinoic Acid Receptors and Cancer [PDF]
The Journal of Nutrition, 2002 Retinoids have been shown to inhibit the growth of many human tumor cells. Although the exact molecular mechanism of retinoid-mediated growth suppression remains known, the importance of the retinoic acid receptors (RARs) and retinoid X receptors (RXRs) has been in established a number of tumor cell models.
Kenneth J, Soprano +1 more
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Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease
Frontiers in Pharmacology, 2022 Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations.
Tapan Behl +11 more
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Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics
Cells, 2020 Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal +3 more
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