Results 31 to 40 of about 62,881 (303)
Neofunctionalization in vertebrates: the example of retinoic acid receptors. [PDF]
PLoS Genetics, 2006 Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies.
Hector Escriva +9 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Pattern recognition receptors (PRRs) play critical roles in recognizing pathogen-derived nucleic acids and inducing innate immune responses, such as inflammation and type I interferon production.
Norisuke Kano +3 more
doaj +1 more source
Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PDF]
PLoS ONE, 2010 Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer.
Shaoteng Han +7 more
doaj +1 more source
Molecular Metabolism, 2022 Objective: The β-carotene oxygenase 1 (BCO1) is the enzyme responsible for the cleavage of β-carotene to retinal, the first intermediate in vitamin A formation. Preclinical studies suggest that BCO1 expression is required for dietary β-carotene to affect
Johana Coronel +4 more
doaj +1 more source
Expression of retinoid receptors during rabbit lung development
Animal, 2007 Rabbit lung is often used to study the pathophysiology of some congenital anomalies affecting the lung because its development is very comparable with that of human.
K. Coste +7 more
doaj +1 more source
Research progress in retinoic acid in cognitive impairment disorders [PDF]
Jichu yixue yu linchuangRetinoic acid (RA), as the principal active metabolite of vitamin A, plays a critical role in regulating neurogenesis, synaptic plasticity, and anti-inflammatory responses.
ZHANG Tengyu, WU Ting, WU Xiang
doaj +1 more source
Antagonism between retinoic acid receptors. [PDF]
Molecular and Cellular Biology, 1991 In the developing mouse, retinoic acid receptors (RARs) beta and gamma 1 are expressed in characteristic spatiotemporal patterns which are correlated with different developmental fates of the respective tissues. Understanding the cues that regulate the expression of the various RARs may therefore provide insights into the process of tissue ...
M, Husmann +5 more
openaire +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors
, 2020 Gametes are generated through a specialized cell differentiation process, meiosis, which, in ovaries of most mammals, is initiated during fetal life. All-trans retinoic acid (ATRA) is considered as the molecular signal triggering meiosis initiation.
Féret, Betty +11 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source