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Retinoic Acid and Retinoid X Receptors [PDF]
Cells, 2023 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
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Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia [PDF]
Biology Open, 2022 Transcriptome analyses performed in both human and zebrafish indicate strong expression of Apoe and Apoc1 by microglia. Apoe expression by microglia is well appreciated, but Apoc1 expression has not been well-examined.
Whitney A. Thiel +4 more
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Long-distance retinoid signaling in the zebra finch brain. [PDF]
PLoS ONE, 2014 All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural ...
Tina C Roeske +4 more
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Retinoic Acid and Its Derivatives in Skin
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +8 more
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LOSS OF RETINOID RECEPTORS RAR-A AND RXR-A DURING MONOCROTALIN/LIPOPOLYSACCHARIDE-INDUCED RENAL TOXICITY IS TISSUE FACTOR DEPENDENT [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2012 Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth, differentiation, survival and death.
Mohamed Abdel-Bakky
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Scientific Reports, 2021 Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti +10 more
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Role of retinoic receptors in lung carcinogenesis
Journal of Experimental & Clinical Cancer Research, 2008 Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions.
Renyi-Vamos Ferenc +4 more
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Haematologica, 2021 RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells ...
Orsola di Martino +7 more
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Retinoids and Cardiac Development
Journal of Developmental Biology, 2014 Retinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during
Stéphane Zaffran +2 more
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Heliyon, 2023 Oxidative stress plays a crucial role in the development of type 2 diabetes and the associated microvascular and cardiovascular complications. In the study, we have investigated the effects of Heinsia crinita (H.
Iwara A. Iwara +10 more
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