Results 41 to 50 of about 23,550 (202)

Human nutritional relevance and suggested nutritional guidelines for vitamin A5/X and provitamin A5/X

Nutrition & Metabolism, 2023
In the last century, vitamin A was identified that included the nutritional relevant vitamin A1 / provitamin A1, as well as the vitamin A2 pathway concept.
Torsten Bohn, Julian Hellman-Regen, Angel R. de Lera, Volker Böhm, Ralph Rühl   +4 more
doaj   +1 more source

Adaptive evolution of the Retinoid X receptor in vertebrates

Genomics, 2012
Retinoid X receptors (RXR) are transcription factors with important roles in development, reproduction, homeostasis, and cell differentiation. Different types of vertebrate RXRs (α (RXRA), ß (RXRB) and γ (RXRG)) have arisen from multiple duplication events.
Philip, Siby, Castro, L. Filipe C., da Fonseca, Rute R., Reis-Henriques, Maria A., Vasconcelos, Vítor, Santos, Miguel M., Antunes, Agostinho   +6 more
openaire   +2 more sources

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang, Chen Zhang, Jia‐Ni Chen, Fu‐Ying Cheng, Yi‐Zhang Wang, Shi‐Rui Xue, Huan Wang, De‐Hui Wang, Xi‐Cai Sun, Li Hu   +9 more
wiley   +1 more source

Effect of LXR/RXR agonism on brain and CSF Aβ40 levels in rats [version 2; referees: 1 approved, 2 approved with reservations]

F1000Research, 2016
Alzheimer's disease (AD) is characterized pathologically by the presence of amyloid plaques and neurofibrillary tangles. The amyloid hypothesis contends that the abnormal accumulation of Aβ, the principal component of amyloid plaques, plays an essential ...
Songli Wang, Paul Wen, Stephen Wood
doaj   +1 more source

Amphibian‐Derived Peptide OA‐AL14 Alleviates UVB‐Induced Skin Photoaging via Autophagy Activation Mediated by the AMPK/mTOR Pathway

Integrative Zoology, EarlyView.
The schematic diagram illustrates that the amphibian‐derived peptide OA‐AL14 protects against UVB‐induced skin photoaging through a dual mechanism: activating the Nrf2 pathway to counteract oxidative stress and modulating the AMPK/mTOR axis to induce protective autophagy. ABSTRACT Skin photoaging, primarily driven by ultraviolet B (UVB) radiation, is a
Ying Peng, Yutong Wu, Zhe Fu, Zijian Kang, Qiuye Jia, Wenbi Zhao, Ziyi Wang, Yuexi Liu, Ruijie Zhang, Yuansheng Li, Zeqiong Ru, Wenrou Su, Naixin Liu, Yilin Li, Saige Yin, Ying Wang, Xinwang Yang   +16 more
wiley   +1 more source

Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne‐Related Post‐Inflammatory Hyperpigmentation: A Cross‐Sectional Study Highlighting the Need for Targeted Education

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real‐world sunscreen practices in this group. This study aimed to evaluate sunscreen use, barriers and factors influencing adherence
Xiaozhun Hang, Davin Sui Lim, Lisa Byrom
wiley   +1 more source

Roles of distinct nuclear receptors in diabetic cardiomyopathy

Frontiers in Pharmacology
Diabetes mellitus induces a pathophysiological disorder known as diabetic cardiomyopathy and may eventually cause heart failure. Diabetic cardiomyopathy is manifested with systolic and diastolic contractile dysfunction along with alterations in unique ...
Yangyang Zheng, Yongji Xu, Li Ji, Wenqing San, Danning Shen, Qianyou Zhou, Guoliang Meng, Jiahai Shi, Yun Chen   +8 more
doaj   +1 more source