Results 51 to 60 of about 23,550 (202)

Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil[S]

Journal of Lipid Research, 2012
Omega-3-PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are associated with prevention of various aspects of metabolic syndrome.
Peter J. Gillies, Sujata K. Bhatia, Leigh A Belcher, Daniel B. Hannon, Jerry T. Thompson, John P. Vanden Heuvel   +5 more
doaj   +1 more source

Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids.

Chemical and Pharmaceutical Bulletin, 1999
Several dibenzodiazepine derivatives were identified as novel retinoid X receptor (RXR) antagonists on the basis of inhibitory activity on retinoid-induced cell differentiation of human promyelocytic leukemia cells HL-60 and transactivation assay using retinoic acid receptors (RARs) and RXRs in COS-1 cells.
EBISAWA, Masayuki, UMEMIYA, Hiroki, OHTA, Kiminori, FUKASAWA, Hiroshi, KAWACHI, Emiko, CHRISTOFFEL, Ghislaine, GRONEMEYER, Hinrich, TSUJI, Motonori, HASHIMOTO, Yuichi, SHUDO, Koichi, KAGECHIKA, Hiroyuki   +10 more
openaire   +3 more sources

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Alternative retinoid X receptor (RXR) ligands

Molecular and Cellular Endocrinology, 2019
Retinoid X receptors (RXRs) control a wide variety of functions by virtue of their dimerization with other nuclear hormone receptors (NRs), contributing thereby to activities of different signaling pathways. We review known RXR ligands as transcriptional modulators of specific RXR-dimers and the associated biological processes.
Wojciech Krężel, Ralph Rühl, Angel R. de Lera   +2 more
openaire   +3 more sources

Identification and functional validation of a novel disease‐causing variant in the noncoding region of NYX

Acta Ophthalmologica, EarlyView.
Abstract Purpose Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders, with ~30% of cases remaining genetically unsolved. Complete congenital stationary night blindness (cCSNB) is a subtype of IRD, usually associated with reduced visual acuity, nystagmus and high myopia.
Filip Spanic, Christelle Michiels, Julien Navarro, Aline Antonio, Christel Condroyer, Camille Andrieu, Billy Gipsy, Sylvie Berthémy‐Pellet, Mathilde Gallice, Isabelle Audo, Christina Zeitz   +10 more
wiley   +1 more source

Epigenetic Silencing of Cellular Retinol-Binding Proteins in Nasopharyngeal Carcinoma

Neoplasia: An International Journal for Oncology Research, 2005
Aberrant retinoid signaling in human cancers is extending from the nucleus to the cytoplasm. Recently, we have demonstrated frequent epigenetic inactivation of a retinoic acid receptor (RAR), RARβ2, in nasopharyngeal carcinoma (NPC).
Joseph Kwong, Kwok-Wai Lo, Lillian Shuk-Nga Chow, Ka-Fai To, Kwong-Wai Choy, Franky Leung Chan, Samuel C. Mok, Dolly P. Huang   +7 more
doaj   +1 more source

Utility of combined CD39/CD73/CD38 expression for the detection of malignant T cells in Sézary syndrome

British Journal of Haematology, EarlyView.
Summary Sézary syndrome (SS) is an aggressive cutaneous T‐cell lymphoma, characterized by erythroderma, lymphadenopathy and circulating malignant CD4+ T cells. Despite therapeutic advances, SS remains an incurable disease. Early diagnosis is therefore essential for timely therapeutic intervention; however, reliable biomarkers to identify circulating SS
Sara Marchisio, Yuliya Yakymiv, Liyun Lin, Erika Ortolan, Verdiana Pullano, Renata Ponti, Fenna J. de Bie, Alita J. van der Sluijs‐Gelling, Willem H. Zoutman, Valentina Pala, Ferenc A. Scheeren, Maarten H. Vermeer, Ada Funaro, Pietro Quaglino, Gabriele Roccuzzo   +14 more
wiley   +1 more source

New ligands of the Cellular Retinoic Acid-Binding Protein 2 (CRABP2) suggest a role for this protein in chromatin remodeling

Revista de Ciências Farmacêuticas Básica e Aplicada, 2014
Retinoic acid (RA) regulates the transcription of a series of genes involved in cell proliferation, differentiation and apoptosis by binding to the RA Receptor (RAR) and Retinoid X Receptor (RXR) heterodimers. The cellular retinoic acid-binding protein 2
Daniella Barros Rossetto, Eric Nishimura Kiyomoto, Carlos Eduardo Brantis de Carvalho, Cleslei Fernando Zanelli, Sandro Roberto Valentini   +4 more
doaj   +2 more sources

Expression of retinoid receptors during rabbit lung development

Animal, 2007
Rabbit lung is often used to study the pathophysiology of some congenital anomalies affecting the lung because its development is very comparable with that of human.
K. Coste, D. Gallot, G. Marceau, J. Jani, J. Deprest, A. Labbé, D. Lémery, V. Sapin   +7 more
doaj   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source