Results 1 to 10 of about 59,484 (114)

The potential of retinoic acid receptors as prognostic biomarkers and therapeutic targets in gastric cancer [PDF]

Frontiers in Oncology
BackgroundGastric cancer is a heterogeneous collection of tumors characterized by low survival rates. All-trans retinoic acid (retinoic-acid) is a clinically useful therapeutic agent belonging to the chemical family of retinoids, which consists of both ...
Silvio Ken Garattini, Debora Basile, Valli’ De Re, Giulia Brisotto, Gianmaria Miolo, Vincenzo Canzonieri, Vincenzo Canzonieri, Giuseppe Aprile, Giuseppe Aprile, Carla Corvaja, Silvia Buriolla, Enrico Garattini, Fabio Puglisi, Fabio Puglisi   +13 more
doaj   +4 more sources

Retinoic Acid and Its Derivatives in Skin

Cells, 2020
The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański, Rafał Skopek, Małgorzata Palusińska, Tino Schenk, Sven Stengel, Sławomir Lewicki, Leszek Kraj, Paweł Kamiński, Arthur Zelent   +8 more
doaj   +3 more sources

The role of RARG in solid tumor progression and therapeutic potential [PDF]

Discover Oncology
Retinoic acid receptor gamma (RARG), a crucial member of the retinoic acid receptors (RARs) family, encompasses two distinct isoforms, namely RARγ1 and RARγ2. RARG is organized into five functional domains: A/B, C, D, E and F.
Shuyan Guo, Haobo Han, Biao Ding, Wentao Zhang, Long Qin   +4 more
doaj   +2 more sources

The Pleiotropic Role of Retinoic Acid/Retinoic Acid Receptors Signaling: From Vitamin A Metabolism to Gene Rearrangements in Acute Promyelocytic Leukemia. [PDF]

Int J Mol Sci, 2019
Conserva MR, Anelli L, Zagaria A, Specchia G, Albano F.   +4 more
europepmc   +2 more sources

Case report: Identification of a novel HNRNPC::RARG fusion in acute promyelocytic leukemia lacking RARA rearrangement

Frontiers in Oncology, 2023
Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia (AML), 95% patients have PML-RARA fusion gene as a result of a reciprocal chromosomal translocation t(15;17)(q22; q21). The retinoic acid receptors (RARs) belong to nuclear
Wenjing Ding, Wenjing Ding, Guangyang Weng, Zheng Wang, Zheng Wang, Yusha Guo, Yusha Guo, Man Wang, Hongjie Shen, Suning Chen, Suning Chen, Xin Du, Lijun Wen, Lijun Wen   +13 more
doaj   +1 more source

Potential Therapeutic Effect of All-Trans Retinoic Acid on Atherosclerosis

Biomolecules, 2022
Atherosclerosis is a major risk factor for myocardial infarction and ischemic stroke, which are the leading cause of death worldwide. All-trans retinoic acid (ATRA) is a natural derivative of essential vitamin A.
Qile Deng, Jixiang Chen
doaj   +1 more source

Retinoic Acid and Retinoid X Receptors

Cells, 2023
One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [...]
Michael Schubert, Pierre Germain
doaj   +1 more source

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

Discover Oncology, 2023
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong, Xiaojun Liu, Weihua Ding, Lizhong Peng, Xuhui Zeng, Yayun Gu   +5 more
doaj   +1 more source

Therapeutic insights elaborating the potential of retinoids in Alzheimer’s disease

Frontiers in Pharmacology, 2022
Alzheimer’s disease (AD) is perceived with various pathophysiological characteristics such oxidative stress, senile plaques, neuroinflammation, altered neurotransmission immunological changes, neurodegenerative pathways, and age-linked alterations.
Tapan Behl, Dapinder Kaur, Aayush Sehgal, Rajeev K. Singla, Rajeev K. Singla, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Hassan A. Alhazmi, Abdulkarim M. Meraya, Simona Bungau, Simona Bungau   +11 more
doaj   +1 more source

Nuclear Receptors as Autophagy-Based Antimicrobial Therapeutics

Cells, 2020
Autophagy is an intracellular process that targets intracellular pathogens for lysosomal degradation. Autophagy is tightly controlled at transcriptional and post-translational levels.
Prashanta Silwal, Seungwha Paik, Sang Min Jeon, Eun-Kyeong Jo   +3 more
doaj   +1 more source