Results 31 to 40 of about 62,977 (257)

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Nature Communications, 2017
Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and ...
Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad   +5 more
doaj   +1 more source

Neofunctionalization in vertebrates: the example of retinoic acid receptors. [PDF]

PLoS Genetics, 2006
Understanding the role of gene duplications in establishing vertebrate innovations is one of the main challenges of Evo-Devo (evolution of development) studies.
Hector Escriva, Stéphanie Bertrand, Pierre Germain, Marc Robinson-Rechavi, Muriel Umbhauer, Jérôme Cartry, Marilyne Duffraisse, Linda Holland, Hinrich Gronemeyer, Vincent Laudet   +9 more
doaj   +1 more source

Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases

Frontiers in Cellular and Infection Microbiology, 2022
Pattern recognition receptors (PRRs) play critical roles in recognizing pathogen-derived nucleic acids and inducing innate immune responses, such as inflammation and type I interferon production.
Norisuke Kano, Guang Han Ong, Daisuke Ori, Taro Kawai   +3 more
doaj   +1 more source

Anti-tumor effect in human lung cancer by a combination treatment of novel histone deacetylase inhibitors: SL142 or SL325 and retinoic acids. [PDF]

PLoS ONE, 2010
Histone deacetylase (HDAC) inhibitors arrest cancer cell growth and cause apoptosis with low toxicity thereby constituting a promising treatment for cancer.
Shaoteng Han, Takuya Fukazawa, Tomoki Yamatsuji, Junji Matsuoka, Hiroyuki Miyachi, Yutaka Maeda, Mary Durbin, Yoshio Naomoto   +7 more
doaj   +1 more source

The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice

Molecular Metabolism, 2022
Objective: The β-carotene oxygenase 1 (BCO1) is the enzyme responsible for the cleavage of β-carotene to retinal, the first intermediate in vitamin A formation. Preclinical studies suggest that BCO1 expression is required for dietary β-carotene to affect
Johana Coronel, Jianshi Yu, Nageswara Pilli, Maureen A. Kane, Jaume Amengual   +4 more
doaj   +1 more source

Expression of retinoid receptors during rabbit lung development

Animal, 2007
Rabbit lung is often used to study the pathophysiology of some congenital anomalies affecting the lung because its development is very comparable with that of human.
K. Coste, D. Gallot, G. Marceau, J. Jani, J. Deprest, A. Labbé, D. Lémery, V. Sapin   +7 more
doaj   +1 more source

Transcriptional Activities of Retinoic Acid Receptors

, 2005
International audienceVitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A.
Dedieu, Stéphane, Dedieu, S., Sébastien Flajollet, Martin, P.J., Lefebvre, Philippe, Philippe Lefebvre, Bruno Lefebvre, Lefebvre, B., Billaut, Xavier, Lefebvre, P., Flajollet, S., Billaut, X., Perrine J. Martin, Martin, Perrine, Xavier Billaut, Stéphane Dedieu, Lefebvre, Bruno, Flajollet, Sébastien   +17 more
core   +1 more source

Research progress in retinoic acid in cognitive impairment disorders [PDF]

Jichu yixue yu linchuang
Retinoic acid (RA), as the principal active metabolite of vitamin A, plays a critical role in regulating neurogenesis, synaptic plasticity, and anti-inflammatory responses.
ZHANG Tengyu, WU Ting, WU Xiang
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source