Journal of Lipid Research, 1992 In this study, we examined effects of retinol deficiency and three retinoids, all-trans-retinoic acid, 13-cis-retinoic acid, and etretin, the aromatic derivative of retinoic acid on nuclear retinoic acid receptor isoforms alpha, beta, and gamma mRNA in ...
Riaz-ul-Haq, F Chytil
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NADPH-cytochrome P450 reductase is regulated by all-trans retinoic acid and by 1,25-dihydroxyvitamin D3 in human acute myeloid leukemia cells. [PDF]
PLoS ONE, 2014 Acute myeloid leukemia (AML) cell lines can be driven to differentiate to monocyte-like cells by 1,25- dihydroxyvitamin D3 (1,25D) and to granulocyte-like cells by all-trans-retinoic acid (ATRA).
Elżbieta Gocek +3 more
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Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. [PDF]
PLoS ONE, 2017 Disruption of nuclear receptors, a transcription factor superfamily regulating gene expression in animals, is one proposed mechanism through which pollution causes effects in aquatic invertebrates.
Susanne Vogeler +3 more
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Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids. [PDF]
PLoS ONE, 2014 The effects of thyroid hormone on brain development and function are largely mediated by the binding of 3,5,3'-triiodo-L-thyronine (T3) to its nuclear receptors (TR) to regulate positively or negatively gene expression.
Pilar Gil-Ibáñez +2 more
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Reproductive Biology and Endocrinology, 2003 Retinoids, a class of compounds that include retinol and its metabolite, retinoic acid, are absolutely essential for ovarian steroid production, oocyte maturation, and early embryogenesis.
Malayer Jerry +2 more
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FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk [PDF]
, 2011 Coordination between functionally related adjacent tissues is essential during development. For example, formation of trunk neural crest cells (NCCs) is highly influenced by the adjacent mesoderm, but the molecular mechanism involved is not well ...
Quiroga, Alejandra C +23 more
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LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]
, 2013 The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
Kay S Childs +16 more
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Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells
Journal of Lipid Research, 2004 An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe +3 more
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Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. [PDF]
PLoS ONE, 2011 Dominant mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of Parkinson's disease, however, little is known about the biological function of LRRK2 protein.
Cathrin Schulz +7 more
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Pathogenesis of retinoic acid-induced spina bifida in rat embryos [PDF]
, 2008 In a previous study, we showed that the intrauterine exposure of rat embryos to retinoic acid (RA) in the organogenesis period (8-11 days of gestation) induced various malformations according to the dose and timing of RA administration.
コニシ, ヒロヨシ +3 more
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