Results 21 to 30 of about 23,550 (202)

Regulation of retinoid-mediated signaling involved in skin homeostasis by RAR and RXR agonists/antagonists in mouse skin.

PLoS ONE, 2013
Endogenous retinoids like all-trans retinoic acid (ATRA) play important roles in skin homeostasis and skin-based immune responses. Moreover, retinoid signaling was found to be dysregulated in various skin diseases.
Janine Gericke, Jan Ittensohn, Johanna Mihály, Susana Alvarez, Rosana Alvarez, Dániel Töröcsik, Angel R de Lera, Ralph Rühl   +7 more
doaj   +1 more source

Phytanic Acid is a Retinoid X Receptor Ligand [PDF]

European Journal of Biochemistry, 1996
Metabolic defects in phytanic acid catabolism have been shown to be connected with a number of human diseases which can lead to lethal defects of the nervous system and other organs. These effects are probably a result of the very high accumulation of phytanic acid in tissues throughout the body, due to defects in phytanic acid oxidation, the ...
P K, Lemotte, S, Keidel, C M, Apfel
openaire   +2 more sources

Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity

Nature Communications, 2019
The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation.
Ashley Penvose, Jessica L. Keenan, David Bray, Vijendra Ramlall, Trevor Siggers   +4 more
doaj   +1 more source

Mediation of antiinflammatory effects of Rg3-enriched red ginseng extract from Korean Red Ginseng via retinoid X receptor α–peroxisome-proliferating receptor γ nuclear receptors

Journal of Ginseng Research, 2019
Background: Ginseng has a wide range of beneficial effects on health, such as the mitigation of minor and major inflammatory diseases, cancer, and cardiovascular diseases. There are abundant data regarding the health-enhancing properties of whole ginseng
Evelyn Saba, Muhammad Irfan, Dahye Jeong, Kashif Ameer, Yuan Yee Lee, Chae-Kyu Park, Seung-Bok Hong, Man Hee Rhee   +7 more
doaj   +1 more source

Auto-silencing by the retinoid X receptor

Journal of Molecular Biology, 1998
Gene transcription is often regulated by small ligands, enabling cells to respond to external and metabolic stimuli. Of particular interest are the mechanisms by which hydrophobic hormones modulate the transcriptional activities of proteins of the nuclear receptor superfamily.
S, Kersten, D, Dong, W y, Lee, P R, Reczek, N, Noy   +4 more
openaire   +2 more sources

DNA Bending by Retinoid X Receptor-Containing Retinoid and Thyroid Hormone Receptor Complexes [PDF]

Molecular and Cellular Biology, 1993
Retinoid X receptors (RXR) have been identified as common subunits in the regulation of multiple hormonal signaling pathways. Using circular permutation and phasing analysis of specific response elements, we present evidence that RXR-retinoic acid receptor and RXR-thyroid hormone receptor heterodimer or RXR-RXR homodimer complexes induce directed DNA ...
X P, Lu, N L, Eberhardt, M, Pfahl
openaire   +2 more sources

Effects of PPARγ Ligands on Leukemia

PPAR Research, 2012
Peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RARs), members of the nuclear receptor superfamily, are transcription factors that regulate a variety of important cellular functions.
Yoko Tabe, Marina Konopleva, Michael Andreeff, Akimichi Ohsaka   +3 more
doaj   +1 more source

Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer’s disease

Neural Regeneration Research, 2019
All retinoids, which can be natural and synthetic, are chemically related to vitamin A. Both natural and synthetic retinoids use specific nuclear receptors such as retinoic acid receptors and retinoid X receptors to activate specific signaling pathways ...
Bhaskar C Das, Somsankar Dasgupta, Swapan K Ray   +2 more
doaj   +1 more source

The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Receptors

Canadian Journal of Gastroenterology, 2003
The coordinated effect of lipid activated nuclear hormone receptors; liver X receptor (LXR), bound by oxysterol ligands and farnesoid X receptor (FXR), bound by bile acid ligands, act as genetic transcription factors to cause feed-forward cholesterol ...
Richard N Redinger
doaj   +1 more source

AEG-1 Regulates Retinoid X Receptor and Inhibits Retinoid Signaling [PDF]

Cancer Research, 2014
Abstract Retinoid X receptor (RXR) regulates key cellular responses such as cell growth and development, and this regulation is frequently perturbed in various malignancies, including hepatocellular carcinoma (HCC). However, the molecule(s) that physically govern this deregulation are mostly unknown.
Jyoti, Srivastava, Chadia L, Robertson, Devaraja, Rajasekaran, Rachel, Gredler, Ayesha, Siddiq, Luni, Emdad, Nitai D, Mukhopadhyay, Shobha, Ghosh, Phillip B, Hylemon, Gregorio, Gil, Khalid, Shah, Deepak, Bhere, Mark A, Subler, Jolene J, Windle, Paul B, Fisher, Devanand, Sarkar   +15 more
openaire   +2 more sources