Results 11 to 20 of about 23,550 (202)

LOSS OF RETINOID RECEPTORS RAR-A AND RXR-A DURING MONOCROTALIN/LIPOPOLYSACCHARIDE-INDUCED RENAL TOXICITY IS TISSUE FACTOR DEPENDENT [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2012
Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth, differentiation, survival and death.
Mohamed Abdel-Bakky
doaj   +1 more source

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors

Scientific Reports, 2021
Retinoid X receptors are members of the nuclear receptor family that regulate gene expression in response to retinoic acid and related ligands. Group 1 metabotropic glutamate receptors are G-protein coupled transmembrane receptors that activate ...
Chirag Upreti, Caitlin M. Woodruff, Xiao-Lei Zhang, Michael J. Yim, Zhen-yu Zhou, Andrew M. Pagano, Dina S. Rehanian, Deqi Yin, Eric R. Kandel, Patric K. Stanton, Russell E. Nicholls   +10 more
doaj   +1 more source

Retinoid-X receptor action and disruption in development. [PDF]

Dev Biol
Mengeling BJ, Furlow JD.
europepmc   +2 more sources

RXRA DT448/9PP generates a dominant active variant capable of inducing maturation in acute myeloid leukemia cells

Haematologica, 2021
RARA and RXRA contribute to myeloid maturation in both mice and humans, and deletion of Rxra and Rxrb augments leukemic growth in mice. While defining the domains of RXRA that are required for anti-leukemic effects in murine KMT2A-MLLT3 leukemia cells ...
Orsola di Martino, Margaret A. Ferris, Gayla Hadwiger, Soyi Sarkar, Anh Vu, María P. Menéndez-Gutiérrez, Mercedes Ricote, John S. Welch   +7 more
doaj   +1 more source

Retinoid X receptors in macrophage biology [PDF]

Trends in Endocrinology & Metabolism, 2013
Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism.
Roszer, Tamas, Menendez-Gutierrez, Maria Piedad, Cedenilla, Marta, Ricote, Mercedes   +3 more
openaire   +3 more sources

Role of retinoic receptors in lung carcinogenesis

Journal of Experimental & Clinical Cancer Research, 2008
Several in vitro and in vivo studies have examined the positive and negative effects of retinoids (vitamin A analogs) in premalignant and malignant lesions.
Renyi-Vamos Ferenc, Bogos Krisztina, Kovacs Gabor, Tovari Jozsef, Dome Balazs   +4 more
doaj   +1 more source

Retinoids and Cardiac Development

Journal of Developmental Biology, 2014
Retinoic acid (RA), a derivative of vitamin A, is involved in signal transduction during vertebrate organogenesis. Retinoids through binding to nuclear receptors called RA receptors (RARs) and retinoid X receptors (RXRs) regulate various processes during
Stéphane Zaffran, Nicolas El Robrini, Nicolas Bertrand   +2 more
doaj   +1 more source

Modulatory effects of extract of Heinsia crinita against fructose/streptozotocin-induced oxidative stress in diabetic rat models

Heliyon, 2023
Oxidative stress plays a crucial role in the development of type 2 diabetes and the associated microvascular and cardiovascular complications. In the study, we have investigated the effects of Heinsia crinita (H.
Iwara A. Iwara, Eve O. Mboso, Oju R. Ibor, Kelvin Elot, Collin Igajah, Andem A. Bassey, Ofem E. Eteng, Bob I.A. Mgbeje, Godwin O. Igile, Mbeh U. Eteng, Augustine Arukwe   +10 more
doaj   +1 more source

Nuclear receptors in neurodegenerative diseases

Neurobiology of Disease, 2014
Nuclear receptors have generated substantial interest in the past decade as potential therapeutic targets for the treatment of neurodegenerative disorders.
Rebecca Skerrett, Tarja Malm, Gary Landreth   +2 more
doaj   +1 more source

Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. [PDF]

PLoS ONE, 2017
Disruption of nuclear receptors, a transcription factor superfamily regulating gene expression in animals, is one proposed mechanism through which pollution causes effects in aquatic invertebrates.
Susanne Vogeler, Tamara S Galloway, Michail Isupov, Tim P Bean   +3 more
doaj   +1 more source