Results 21 to 30 of about 3,042,168 (292)

Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells

Journal of Lipid Research, 2004
An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe, Heather K. Poucher, Miki Hiraoka, James A. Shayman   +3 more
doaj   +1 more source

Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. [PDF]

PLoS ONE, 2011
Dominant mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of Parkinson's disease, however, little is known about the biological function of LRRK2 protein.
Cathrin Schulz, Marie Paus, Katharina Frey, Ramona Schmid, Zacharias Kohl, Detlev Mennerich, Jürgen Winkler, Frank Gillardon   +7 more
doaj   +1 more source

Pathogenesis of retinoic acid-induced spina bifida in rat embryos [PDF]

, 2008
In a previous study, we showed that the intrauterine exposure of rat embryos to retinoic acid (RA) in the organogenesis period (8-11 days of gestation) induced various malformations according to the dose and timing of RA administration.
コニシ, ヒロヨシ, 小西, 啓悦, 1430, Konishi, Hiroyoshi   +3 more
core   +1 more source

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source

Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis [PDF]

International Journal of Ophthalmology, 2015
Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response.
Hong-Yan Zhou, Wei Zhong, Hong Zhang, Miao-Miao Bi, Shuang Wang, Wen-Song Zhang   +5 more
doaj   +1 more source

Beta-carotene Reduces Body Adiposity of Mice Via BCMO1 [PDF]

, 2011
Evidence from cell culture studies indicates that ß-carotene-(BC)-derived apocarotenoid signaling molecules can modulate the activities of nuclear receptors that regulate many aspects of adipocyte physiology.
Yvonne G. J. van Helden, Georg Lietz, Kiec-Wilk, B., Andreu Palou, Adrian Wyss, von Lintig, J., Jean François Landrier, Landrier, Jean-Francois, Ursula Razny, Lietz, G., Raźny, Urszula, Kramer, E.H.M., Amengual, J., Wyss, A., Kramer, Evelien, Lietz, Georg, Gouranton, Erwan, M. Luisa Bonet, Razny, Ursula, Beata Kiec-Wilk, van Helden, Y.G., M Luisa Bonet, Joan Ribot, Susanne Hessel, Aldona Dembinska-Kiec, Jaap Keijer, Landrier, Jean François, Yvonne G J van Helden, Keijer, J., Hessel, S., Dembinska-Kiec, Aldona, Amengual, Jaume, Keijer, Jaap, Landrier, J. F., Bonet, M. Luisa, Ribot, Joan, Kramer, E., Dembinska-Kiec, A., Gouranton, E., Palou, Andreu, Kiec-Wilk, Beata, Ribot, J., Erwan Gouranton, Palou, A., Razny, U., Helden, Y.G.J., Johannes von Lintig, Wyss, Adrian, Hessel, Susanne, Evelien Kramer, van Helden, Yvonne G. J., Luisa Bonet, M., von Lintig, Johannes, Bonet, M.L., Jaume Amengual   +54 more
core   +2 more sources

Tumour–stroma interactions in an organotypic culture model of pancreatic cancer [PDF]

, 2011
PhDPancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the ...
Froeling, Fieke E.M.
core   +4 more sources

In Vivo Imaging of Retinoic Acid Receptor Activity using a Sodium/Iodide Symporter and Luciferase Dual Imaging Reporter Gene

Molecular Imaging, 2004
Retinoic acids are natural derivatives of vitamin A, and play important roles in modulating tumor cell growth by regulating differentiation, thus suggesting the potential use of these derivatives in cancer therapy and prevention.
Min Kyung So, Joo Hyun Kang, June-Key Chung, Yong Jin Lee, Jae Hoon Shin, Kwang Il Kim, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee   +8 more
doaj   +1 more source

Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

Translational Oncology, 2021
Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths worldwide.
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr   +7 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source