Results 21 to 30 of about 62,881 (303)

Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. [PDF]

PLoS ONE, 2011
Dominant mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most prevalent cause of Parkinson's disease, however, little is known about the biological function of LRRK2 protein.
Cathrin Schulz, Marie Paus, Katharina Frey, Ramona Schmid, Zacharias Kohl, Detlev Mennerich, Jürgen Winkler, Frank Gillardon   +7 more
doaj   +1 more source

Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis [PDF]

International Journal of Ophthalmology, 2015
Fungal keratitis (FK) is a worldwide visual impairment disease. This infectious fungus initiates the primary innate immune response and, later the adaptive immune response.
Hong-Yan Zhou, Wei Zhong, Hong Zhang, Miao-Miao Bi, Shuang Wang, Wen-Song Zhang   +5 more
doaj   +1 more source

In Vivo Imaging of Retinoic Acid Receptor Activity using a Sodium/Iodide Symporter and Luciferase Dual Imaging Reporter Gene

Molecular Imaging, 2004
Retinoic acids are natural derivatives of vitamin A, and play important roles in modulating tumor cell growth by regulating differentiation, thus suggesting the potential use of these derivatives in cancer therapy and prevention.
Min Kyung So, Joo Hyun Kang, June-Key Chung, Yong Jin Lee, Jae Hoon Shin, Kwang Il Kim, Jae Min Jeong, Dong Soo Lee, Myung Chul Lee   +8 more
doaj   +1 more source

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source

Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

Translational Oncology, 2021
Despite advances in personalised medicine and the emerging role of immune checkpoints in directing treatment decisions in subsets of lung cancer patients, non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related deaths worldwide.
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr   +7 more
doaj   +1 more source

A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter [PDF]

Molecular Endocrinology, 1990
The morphogen retinoic acid (RA) regulates gene transcription by interacting with specific nuclear receptors that recognize DNA sequences near responsive promoters. While much has recently been learned about the nuclear receptor proteins, little is known about the genes that are directly regulated by RA and their cis-acting response elements recognized
B, Hoffmann, J M, Lehmann, X K, Zhang, T, Hermann, M, Husmann, G, Graupner, M, Pfahl   +6 more
openaire   +2 more sources

Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and Prognosis

Frontiers in Oncology, 2022
Acute promyelocytic leukemia (APL) accounts for 10–15% of newly diagnosed acute myeloid leukemias (AML) and is typically caused by the fusion of promyelocytic leukemia with retinoic acid receptor α (RARA) gene.
Luca Guarnera, Tiziana Ottone, Tiziana Ottone, Emiliano Fabiani, Emiliano Fabiani, Mariadomenica Divona, Arianna Savi, Serena Travaglini, Giulia Falconi, Paola Panetta, Maria Cristina Rapanotti, Maria Cristina Rapanotti, Maria Teresa Voso, Maria Teresa Voso   +13 more
doaj   +1 more source

1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes.

, 1996
1,25 (OH)(2) Vitamin D-3 (VD3) and retinoic acid (RA) function as ligands for nuclear receptors which regulate transcription, Though the cardiovascular system is not thought to represent a classical target for these ligands, it is clear that both cardiac
Gardner, D. G., J Wu, Garami, Miklós, Cheng, T., T Cheng, Wu, J., M Garami, D G Gardner   +7 more
core   +1 more source

A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development [PDF]

, 2010
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived ...
Dabouras, Vasilios, Marino, Daniela, Vasilios Dabouras, Detmar, Michael, Braendli, Andre W., Michael Detmar, André W. Brändli, Daniela Marino   +7 more
core   +1 more source

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission

Nature Communications, 2017
Nuclear receptors (NR) are multidomain proteins, which makes their crystallization challenging. Here the authors present the crystal structure of the retinoic acid receptor β–retinoic X receptor α (RARβ–RXRα) heterodimer bound to DNA, ligands and ...
Vikas Chandra, Dalei Wu, Sheng Li, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad   +5 more
doaj   +1 more source