Results 31 to 40 of about 6,065,806 (347)

Effects of diet and strain on mouse serum and tissue retinoid concentrations. [PDF]

PLoS ONE, 2014
The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of ...
Kristin M Obrochta, Maureen A Kane, Joseph L Napoli   +2 more
doaj   +1 more source

Accumulation of hypoxia-inducible factor-1α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid

Haematologica, 2008
Background The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces ...
Jing Zhang, Li-Ping Song, Ying Huang, Qian Zhao, Ke-Wen Zhao, Guo-Qiang Chen   +5 more
doaj   +1 more source

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

Discover Oncology, 2023
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong, Xiaojun Liu, Weihua Ding, Lizhong Peng, Xuhui Zeng, Yayun Gu   +5 more
doaj   +1 more source

Retinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies.

Advances in Nutrition, 2019
Vitamin A is a fat-soluble essential nutrient obtained from plant- and animal-based sources that has roles in growth, vision, and metabolism. Vitamin A circulates mainly as retinol bound to retinol-binding protein 4 (RBP4), and is delivered to tissues ...
T. Olsen, R. Blomhoff
semanticscholar   +1 more source

Retinoic acid and microRNA

, 2020
Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational ...
Lijun, Wang, Atharva Piyush, Rohatgi, Yu-Jui Yvonne, Wan   +2 more
openaire   +3 more sources

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

Journal of Experimental Medicine, 2007
To maintain immune homeostasis, the intestinal immune system has evolved redundant regulatory strategies. In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3+ T reg cell.
Cheng-Ming Sun, Jason A. Hall, Jason A. Hall, R. Blank, N. Bouladoux, M. Oukka, J. Mora, Y. Belkaid   +7 more
semanticscholar   +1 more source

Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis

Reproductive Toxicology, 2019
Retinoids are essential for reproduction. Most research has focused on the role of retinoic acid signaling in the regulation of meiosis during early fetal germ cell development.
P. Damdimopoulou, Catheryne Chiang, J. Flaws   +2 more
semanticscholar   +1 more source

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source

Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells.

PLoS ONE, 2012
The retinoids, the natural or synthetic derivatives of Vitamin A (retinol), are essential for the normal development of prostate and have been shown to modulate prostate cancer progression in vivo as well as to modulate growth of several prostate cancer ...
Linda Kelsey, Parul Katoch, Kristen E Johnson, Surinder K Batra, Parmender P Mehta   +4 more
doaj   +1 more source

13-cis-retinoic acid is an endogenous compound in human serum.

Journal of Lipid Research, 1990
The occurrence of 13-cis-retinoic acid as an endogenous component in human serum has been confirmed by cochromatography with standards in both normal-phase and reverse-phase high-performance liquid chromatographic (HPLC) system, by the lambda max of its ...
GW Tang, RM Russell
doaj   +1 more source