Results 51 to 60 of about 2,616,742 (302)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Journal of Lipid Research, 1974 A study was conducted to explore the relationship between the effects of vitamin A upon cartilage and the biological role of vitamin A in maintaining growth and life. Retinol, retinoic acid, α-retinoic acid, and RO8-7699 (a cyclopentyl analog of retinoic
DeWitt S. Goodman +3 more
doaj +1 more source
THE ROLE OF RETINOIC ACID IN DIRECTING INITIATION OF SPERMATOGENESIS IN THE MOUSE
, 2023 The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization.
Busada, Jonathan T. +1 more
core
Identification of novel retinoic acid target genes [PDF]
, 2014 Retinoic acid is required for diverse ontogenic processes and as such identification of the genes and pathways affected by retinoic acid is critical to understanding these pleiotropic effects.
Hess, Bradley +4 more
core +1 more source
Advanced Functional Materials, EarlyView.This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu +14 more
wiley +1 more source
Tumour–stroma interactions in an organotypic culture model of pancreatic cancer [PDF]
, 2011 PhDPancreatic cancer is characterised by an intense fibrotic, or desmoplastic, stroma, which contributes to tumour progression. Three-dimensional in vitro culture models incorporating this non-tumour component may more closely recapitulate the ...
Froeling, Fieke E.M.
core +4 more sources
Evaluation of the Effects of Different Concentrations All-trans Retinoic Acid on the Survival of Bone Marrow Mesenchymal Stem Cells [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2018 Background: According to application of Retinoic acid in differentiation of the stem cells to different cells and its role in apoptotic of cancer cells, the selection of appropriate dose for differentiation of stem cells is important.
Maryam Salem +3 more
doaj
Laboratory Animal Research, 2022 Background Retinoic acid is a major metabolite of vitamin A and exerts beneficial effects including anti-oxidant and anti-inflammatory activities in neurons.
Ju-Bin Kang +3 more
doaj +1 more source
, 2023 Douglas G McMahon,1 John E Dowling2 1Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37235, USA; 2Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USACorrespondence: Douglas G McMahon ...
Dowling JE, McMahon DG
core
Charting Morphotoxicity With Complementary Embryo Models
Advanced Healthcare Materials, EarlyView.Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx +9 more
wiley +1 more source