Results 71 to 80 of about 2,794,061 (304)
پزشکی بالینی ابن سینا, 2013 Introduction & Objective: All-trans retinoic acid, a derivative of retinoids, is widely used to in-duce prolifferation, differentiation and apoptosis in normal, precancareous and cancerous cells. Cisplatin, an effective drug for cancer treatment, induces
Noruz Najafzadeh +3 more
doaj
Retinoic Acid Signaling during Early Spinal Cord Development
Journal of Developmental Biology, 2014 Retinoic acid signaling is required at several steps during the development of the spinal cord, from the specification of generic properties to the final acquisition of neuronal subtype identities, including its role in trunk neural crest development ...
Ruth Diez del Corral, Aixa V. Morales
doaj +1 more source
Advanced Science, EarlyView.Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu +20 more
wiley +1 more source
The Retinol-Retinoic Acid Homeostatic System.
, 2013 The Retinol-Retinoic Acid Homeostatic System.
Chao-Ming Chuang (306713) +6 more
core +1 more source
Advanced Science, EarlyView.Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie +24 more
wiley +1 more source
The expression of mRNA for retinoic acid receptor beta (RAR-beta) was induced by all trans-retinoic acid in murine S91 melanoma cells. The induction of RAR-beta was dose-dependent, rapid and insensitive to cycloheximide. Both 13-cis-retinoic acid and 3,4-
Latham JAE, Daly AK, Redfern CPF, Todd C
core +2 more sources
Acute Myelogenous Leukemia without Maturation with a Retinoic Alpha-Receptor Deletion: A Case Report
Case Reports in Oncology, 2014 Acute promyelocytic leukemia (APL) is characterized by a t(15;17) which fuses the 17q retinoic acid alpha-receptor sequence to the 15q PML gene sequence.
Christopher Trosclair +4 more
doaj +1 more source
Generation of Retinaldehyde for Retinoic Acid Biosynthesis
, 2019 The concentration of all-trans-retinoic acid, the bioactive derivative of vitamin A, is critically important for the optimal performance of numerous physiological processes. Either too little or too much of retinoic acid in developing or adult tissues is
Natalia Y. Kedishvili +3 more
core +1 more source
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
, 2013 Microarray data depicting stromal genes regulated by retinoic acid (>1.5 fold change in expression); also shown retinoic acid suppressed genes.
Kai M. Schmidt-Ott (504440) +9 more
core +1 more source