Results 81 to 90 of about 2,616,742 (302)
Retinoic Acid Isomers Applied to Human Skin in Vivo Each Induce a 4-Hydroxylase That Inactivates Only Trans Retinoic Acid [PDF]
, 1996 Application of all-trans retinoic acid to human skin for 4 d under occlusion produces a marked increase in retinoic acid 4-hydroxylase activity. In this study, the possible induction of other hydroxylases in response to 9-cis and 13-cis retinoic acid ...
Kang, Sewon +2 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
Origin of some derivatives of retinoic acid found in rat bile
Journal of Lipid Research, 1968 After the intraportal injection of retinoic acid-15-14C into rats, all-trans methyl retinoate, a cis isomer of methyl retinoate, retinoyl β-glucurono-γ-lactone, retinoic acid, and retinoyl β-glucuronide were isolated from methanol extracts of rat bile by
Kenneth Lippel, James Allen Olson
doaj +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Journal of Lipid Research, 1990 A study was conducted to explore the effects of retinoic acid, fed to retinol-deficient rats, on the tissue distribution and levels of cellular retinol-binding protein (CRBP) and cellular retinoic acid-binding protein (CRABP).
W S Blaner +4 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang +16 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long +3 more
wiley +1 more source
Retinoic acid signaling and the initiation of mammary gland development [PDF]
, 2012 Retinoic acid receptors (RARs), which are involved in retinoic acid signal transduction, are essential for maintaining the differentiated state of epithelial tissues.
Cho, KW +13 more
core +2 more sources
, 1992 Matings between normal young adult ac/ae female mice and heterozygous Quinky BALB/c males were used to study reported teratogenic and/or preventive effects of retinoic acid (RA) utilizing a mutation that produces neural tube defects (NTDs).
Abou-Tarboush, F.M.
core