Results 101 to 110 of about 6,065,806 (347)
Advanced Science, EarlyView.Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang +23 more
wiley +1 more source
Formation of neural and epidermal lineages during the differentiation of human embryonal carcinomacells [PDF]
, 2003 Within the ectoderm of the developing human embryo, cell fate determination is largely modulated by factors activated by cell-to-cell signalling. In vertebrates, ectoderm primarily differentiates into neural cells that make up the central nervous system ...
Christie, Victoria Buyers
core
British Journal of Cancer, 2007 Isomerisation to all-trans-retinoic acid (ATRA) is widely accepted as the key mechanism underlying the favourable clinical properties of 13-cis-retinoic acid (13cisRA).
J. Armstrong +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan +24 more
wiley +1 more source
Origin of some derivatives of retinoic acid found in rat bile
Journal of Lipid Research, 1968 After the intraportal injection of retinoic acid-15-14C into rats, all-trans methyl retinoate, a cis isomer of methyl retinoate, retinoyl β-glucurono-γ-lactone, retinoic acid, and retinoyl β-glucuronide were isolated from methanol extracts of rat bile by
Kenneth Lippel, James Allen Olson
doaj +1 more source
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
OncoTarget, 2015 Hutchinson Gilford progeria syndrome is a fatal disorder characterized by accelerated aging, bone resorption and atherosclerosis, caused by a LMNA mutation which produces progerin, a mutant lamin A precursor.
C. Pellegrini +7 more
semanticscholar +1 more source
Advanced Science, EarlyView.This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen +7 more
wiley +1 more source
, 2008 Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation which is controlled by histone deacetylase (HD), the study
Viroj Wiwanitkit, Wiwanitkit, Viroj
core
Advanced Science, EarlyView.We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu +11 more
wiley +1 more source