Results 61 to 70 of about 6,065,806 (347)

Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration

Therapeutic Advances in Hematology, 2021
Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene.
Xiaoyan Han, Chunxiang Jin, Gaofeng Zheng, Yi Li, Yungui Wang, Enfan Zhang, Honghu Zhu, Zhen Cai   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source

A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved]

F1000Research, 2022
Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application.
Mulyoto Pangestu, Ria Margiana, Cennikon Pakpahan   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evaluation and comparison of natural and synthetic retinoids on model of neural development [PDF]

, 2008
Vitamin A and its derivatives, collectively termed retinoids, are a group of natural and synthetic molecules that are structurally and/or functionally analogous.
Buyers Christie, Victoria
core  

Evaluation of the Effects of Different Concentrations All-trans Retinoic Acid on the Survival of Bone Marrow Mesenchymal Stem Cells [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2018
Background: According to application of Retinoic acid in differentiation of the stem cells to different cells and its role in apoptotic of cancer cells, the selection of appropriate dose for differentiation of stem cells is important.
Maryam Salem, Abolfazl Bayrami, Tooba Mirzapour, Mohsen Sagha   +3 more
doaj  

Comparison of the effects of vitamin A and its analogs upon rabbit ear cartilage in organ culture and upon growth of the vitamin A-deficient rat

Journal of Lipid Research, 1974
A study was conducted to explore the relationship between the effects of vitamin A upon cartilage and the biological role of vitamin A in maintaining growth and life. Retinol, retinoic acid, α-retinoic acid, and RO8-7699 (a cyclopentyl analog of retinoic
DeWitt S. Goodman, John Edgar Smith, Rosalind M. Hembry, John T. Dingle   +3 more
doaj   +1 more source

Retinoic acid regulates the ubiquitin–proteasome system in a middle cerebral artery occlusion animal model

Laboratory Animal Research, 2022
Background Retinoic acid is a major metabolite of vitamin A and exerts beneficial effects including anti-oxidant and anti-inflammatory activities in neurons.
Ju-Bin Kang, Murad-Ali Shah, Dong-Ju Park, Phil-Ok Koh   +3 more
doaj   +1 more source

RETINOIC ACID SYNTHESIS AND DEGRADATION

Sub-cellular biochemistry, 2016
Retinoic acid was identified as the biologically active form of vitamin A almost 70 years ago, but the exact enzymes and control mechanisms that regulate its biosynthesis and degradation are yet to be fully defined.
N. Kedishvili
semanticscholar   +1 more source