Results 11 to 20 of about 6,065,806 (347)
The interplay between retinoic acid binding proteins and retinoic acid degrading enzymes in modulating retinoic acid concentrations. [PDF]
Curr Top Dev BiolThe active metabolite of vitamin A, all-trans-retinoic acid (atRA), is critical for maintenance of many cellular processes. Although the enzymes that can synthesize and clear atRA in mammals have been identified, their tissue and cell-type specific roles are still not fully established.
Isoherranen N, Wen YW.
europepmc +4 more sources
Retinoic Acid and Its Derivatives in Skin
Cells, 2020 The retinoids are a group of compounds including vitamin A and its active metabolite all-trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple organ systems, are essential for normal immune competence, and are ...
Łukasz Szymański +2 more
exaly +2 more sources
International Journal of Applied and Basic Medical Research, 2017 Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug.
Mondal, Dipankar +2 more
openaire +4 more sources
COVID-19: Endogenous Retinoic Acid Theory and Retinoic Acid Depletion Syndrome
Medical Hypotheses, 2020 This study presents two new concepts and definitions to the medical literature. One of those is “endogenous retinoic acid theory” and the other “retinoic acid depletion syndrome”.
Aziz Rodan Sarohan
exaly +2 more sources
Mechanisms of retinoic acid signalling and its roles in organ and limb development
Nature Reviews Molecular Cell Biology, 2015 Retinoic acid (RA) signalling has a central role during vertebrate development. RA synthesized in specific locations regulates transcription by interacting with nuclear RA receptors (RARs) bound to RA response elements (RAREs) near target genes.
Thomas J Cunningham +2 more
exaly +2 more sources
Generation of Retinaldehyde for Retinoic Acid Biosynthesis
Biomolecules, 2019 The concentration of all-trans-retinoic acid, the bioactive derivative of vitamin A, is critically important for the optimal performance of numerous physiological processes. Either too little or too much of retinoic acid in developing or adult tissues is
O. Belyaeva +3 more
semanticscholar +2 more sources
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cell, 2017 Nina Cabezas-Wallscheid +2 more
exaly +2 more sources
Regulation of Prefrontal Patterning and Connectivity by Retinoic Acid
Nature, 2021 The prefrontal cortex (PFC) and its connections with the mediodorsal thalamus are crucial for cognitive flexibility and working memory1 and are thought to be altered in disorders such as autism2,3 and schizophrenia4,5.
Miki Shibata +10 more
semanticscholar +1 more source
Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues
Scientific Reports, 2021 Retinoids play a pivotal role in adrenal development and differentiation. Recent clinical trials revealed therapeutic potential of both all-trans and 9-cis retinoic acid in patients with cortisol excess due to a pituitary ACTH-secreting adenoma and ...
Francesca Pecori Giraldi +4 more
doaj +1 more source
Microbial Production of Bioactive Retinoic Acid Using Metabolically Engineered Escherichia coli
Microorganisms, 2021 Microbial production of bioactive retinoids, including retinol and retinyl esters, has been successfully reported. Previously, there are no reports on the microbial biosynthesis of retinoic acid.
Minjae Han, Pyung Cheon Lee
doaj +1 more source