Results 11 to 20 of about 2,794,061 (304)

Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers

Clinical Breast Cancer, 2013
Molecular segmentation of breast cancer allows identification of small groups of patients who present high sensitivity to targeted agents. A patient, with chemo- and trastuzumab-resistant HER2-overexpressing breast cancer, who presented concomitant acute
A. Goubar, V. Scott, S. Alsafadi, C. Even, V. Quidville, L. Albiges, F. André, J. Guegan, V. Lazar, J. C. Ahomadegbe, DIECI, MARIA VITTORIA, C. Falet, F. Commo, S. Delaloge   +13 more
core   +4 more sources

Inhibition of thrombin, an unexplored function of retinoic acid

Biochemistry and Biophysics Reports, 2019
Retinoic acid, a derivative of vitamin A, is known to possess in vivo anti-inflammatory, anti-platelet and fibrinolytic activities. We have investigated the in vitro thrombin and platelet aggregation inhibitory activities of vitamin A (retinol) and its ...
Tirumala Harikrishna Anantha Krishna, Subban Kamalraj, Maheswaraiah Anikisetty, K. Akhilender Naidu, William R. Surin, Chelliah Jayabaskaran   +5 more
doaj   +2 more sources

FGF and retinoic acid activity gradients control the timing of neural crest cell emigration in the trunk [PDF]

, 2011
Coordination between functionally related adjacent tissues is essential during development. For example, formation of trunk neural crest cells (NCCs) is highly influenced by the adjacent mesoderm, but the molecular mechanism involved is not well ...
Quiroga, Alejandra C, Kate G. Storey, Barbas, Julio A., Storey, Kate G, Morales, Aixa V., Alejandra C. Quiroga, Storey, Kate G., Das, R. M., Quiroga, Alejandra C., Barbas, Julio A, Aixa V. Morales, Raman M. Das, Das, Raman M., Morales, Aixa V, Olivera-Martinez, Isabel, Ruth Diez del Corral, Patricia L. Martínez-Morales, Julio A. Barbas, Martinez-Morales, Patricia L., Olivera-Martínez, I., Isabel Olivera-Martínez, Martínez-Morales, Patricia L, Diez del Corral, Ruth, Das, Raman M; id_orcid   +23 more
core   +1 more source

Retinoic acid embryopathy

International Journal of Applied and Basic Medical Research, 2017
Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug.
Mondal, Dipankar, R Shenoy, Sreekanth, Mishra, Santisena   +2 more
openaire   +3 more sources

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

Discover Oncology, 2023
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial role in regulating cellular receptors’ signaling transduction to downstream pathways and exert multifaceted roles in regulating signaling pathways, cell survival ...
Kun Zhong, Xiaojun Liu, Weihua Ding, Lizhong Peng, Xuhui Zeng, Yayun Gu   +5 more
doaj   +1 more source

Accumulation of hypoxia-inducible factor-1α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid

Haematologica, 2008
Background The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces ...
Jing Zhang, Li-Ping Song, Ying Huang, Qian Zhao, Ke-Wen Zhao, Guo-Qiang Chen   +5 more
doaj   +1 more source

Effects of diet and strain on mouse serum and tissue retinoid concentrations. [PDF]

PLoS ONE, 2014
The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of ...
Kristin M Obrochta, Maureen A Kane, Joseph L Napoli   +2 more
doaj   +1 more source

Phospholipase C-η2 interacts with nuclear and cytoplasmic LIMK-1 during retinoic acid-stimulated neurite growth [PDF]

, 2015
We gratefully acknowledge financial support from the Wellcome Trust (Grant No. WT089803MA to J.M.L.) and the School of Medicine, University of St Andrews.Neurite growth is central to the formation and differentiation of functional neurons and recently ...
Mohammed Arastoo, John M. Lucocq, Hacker, Christian, Lucocq, John Milton, Arastoo, Mohammed, Popovics, Petra, Stewart, Alan J., Christian Hacker, Alan J. Stewart, Petra Popovics, Stewart, Alan J.; id_orcid   +10 more
core   +1 more source

Retinoic acid and microRNA

, 2020
Retinoic acid (RA), the biologically active metabolite of vitamin A, regulates a vast spectrum of biological processes, such as cell differentiation, proliferation, apoptosis, and morphogenesis. microRNAs (miRNAs) play a crucial role in regulating gene expression by binding to messenger RNA (mRNA) which leads to mRNA degradation and/or translational ...
Lijun, Wang, Atharva Piyush, Rohatgi, Yu-Jui Yvonne, Wan   +2 more
openaire   +3 more sources

Endogenous retinoic acid activity in principal cells and intercalated cells of mouse collecting duct system.

PLoS ONE, 2011
BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors.
Yuen Fei Wong, Jeffrey B Kopp, Catherine Roberts, Peter J Scambler, Yoshifusa Abe, Alexandra C Rankin, Neelanjana Dutt, Bruce M Hendry, Qihe Xu   +8 more
doaj   +1 more source