Results 11 to 20 of about 222,098 (349)

Retinoic acid embryopathy

International Journal of Applied and Basic Medical Research, 2017
Isotretinoin is a retinoid which is derived from Vitamin A. It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug.
Mondal, Dipankar, R Shenoy, Sreekanth, Mishra, Santisena   +2 more
openaire   +3 more sources

The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer [PDF]

, 2014
Peer reviewedPublisher ...
Alnabulsi, Ayham, Blihoghe, Daniela, Brown, Gordon T, Cash, Beatriz Giminez, Johansson, Petronella, Murray, Graeme I   +5 more
core   +12 more sources

Quantification of retinoic acid by gas-liquid chromatography-mass spectrometry: total versus all-trans-retinoic acid in human plasma.

Journal of Lipid Research, 1985
An assay based on negative ion chemical ionization mass spectrometry has been developed to quantify retinoic acid in plasma or serum. The lower limit of detection is 75 pg (240 fmol); normal values of retinoic acid can be determined on as little as 40 ...
J L Napoli, B C Pramanik, J B Williams, M I Dawson, P D Hobbs   +4 more
doaj   +1 more source

Unexpected evolutionary proximity of eukaryotic and cyanobacterial enzymes responsible for biosynthesis of retinoic acid and its oxidation [PDF]

, 2014
Biosynthesis of retinoic acid from retinaldehyde (retinal) is catalysed by an aldehyde dehydrogenase (ALDH) and its oxidation by cytochrome P450 enzymes (CYPs).
Gallagher, Connor, Marsh, Andrew, Millard, Andrew D., Scanlan, David J., Taylor, Paul C.   +4 more
core   +1 more source

2-Bromopalmitate targets retinoic acid receptor alpha and overcomes all-trans retinoic acid resistance of acute promyelocytic leukemia

Haematologica, 2019
Fatty acid oxidation dependency of leukemia cells has been documented in recent studies. Pharmacologic inhibition of fatty acid oxidation, thereby, displays significant effects in suppressing leukemia.
Ying Lu, Jin-Song Yan, Li Xia, Kang Qin, Qian-Qian Yin, Hong-Tao Xu, Meng-Qing Gao, Xiao-Ning Qu, Yu-Ting Sun, Guo-Qiang Chen   +9 more
doaj   +1 more source

Fee Arrangements and Fee Shifting: Lessons From the Experience in Ontario [PDF]

, 1984
About one-third of oestrogen receptor alpha-positive breast cancer patients treated with tamoxifen relapse. Here we identify the nuclear receptor retinoic acid receptor alpha as a marker of tamoxifen resistance. Using quantitative mass spectrometry-based
Forshed, Jenny, Helou, Khalil, Hjerpe, Anders, Hultin-Rosenberg, Lina, Johansson, Henrik J., Kanter, Lena, Kovacs, Aniko, Krawiec, Kamilla, Lehtio, Janne, Linderholm, Barbro K., Lundgren, Bo, Martens, Ulf, Mathe, Gyongyver, Mundt, Filip, Panizza, Elena, Sanchez, Betzabe C., Stål, Olle, Yakhini, Zohar   +17 more
core   +3 more sources

Identification and quantitation of all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in human plasma.

Journal of Lipid Research, 1990
Human plasma was analyzed by high performance liquid chromatography for the presence of retinoic acid and 4-oxoretinoic acid isomers. Peaks that coeluted with the reference compounds all-trans-retinoic acid, 13-cis-retinoic acid, and 13-cis-4-oxoretinoic
C Eckhoff, H Nau
doaj   +1 more source

Transcriptional changes in chick wing bud polarization induced by retinoic acid [PDF]

, 2017
BACKGROUND: Retinoic acid is implicated in the induction of the gene encoding Sonic hedgehog (Shh) that specifies antero-posterior positional values and promotes growth of the developing limb bud.
Bangs, Benga, Capdevila, Charite, Chaube, Chinnaiya, Cunningham, Davey, Deschamps, Drossopoulou, Francis-West, Hamburger, Helms, Helms, Kauffmann, Mallo, Mercader, Mercader, Niederreither, Noji, Ogura, Pickering, Probst, Riddle, Ros, Rosello-Diez, Rosello-Diez, Saiz-Lopez, Saunders, Saunders, Scherz, Stratford, Summerbell, Thaller, Tickle, Tickle, Tickle, Tickle, Towers, Towers, Tzchori, Wanek, Welscher, Welten, Wilde, Wolpert, Xu, Xu, Zakany   +48 more
core   +1 more source

Effects of diet and strain on mouse serum and tissue retinoid concentrations. [PDF]

PLoS ONE, 2014
The relationship between dietary vitamin A and all-trans-retinoic acid levels in serum and tissues had not been quantified. We determined the impact of dietary vitamin A on retinoid levels in serum, liver, kidney, testis, and epididymal white adipose of ...
Kristin M Obrochta, Maureen A Kane, Joseph L Napoli   +2 more
doaj   +1 more source

Accumulation of hypoxia-inducible factor-1α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid

Haematologica, 2008
Background The clinical activities of all-trans retinoic acid in the treatment of acute promyelocytic leukemia, a unique subtype of acute myeloid leukemia, have triggered extensive studies aimed at defining the mechanisms by which this compound induces ...
Jing Zhang, Li-Ping Song, Ying Huang, Qian Zhao, Ke-Wen Zhao, Guo-Qiang Chen   +5 more
doaj   +1 more source