Robust Diagnostic and Therapeutic Biomarkers for Tuberculosis Identified Through Multi‐Omics and Mendelian Randomization Analysis [PDF]
MedCommTuberculosis (TB) remains a major global health challenge. In this study, we applied UPLC‐MS/MS lipidomics and data‐independent acquisition proteomics to profile plasma from healthy controls, active TB patients, and cured individuals to identify ...
Chenglin Zhu +9 more
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Nanomaterials, 2023 Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio +3 more
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Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination. [PDF]
PLoS ONE, 2015 STRA6 is a plasma membrane protein that mediates the transport of vitamin A, or retinol, from plasma retinol binding protein (RBP) into the cell. Mutations in human STRA6 are associated with Matthew-Wood syndrome, which is characterized by severe ...
Conor J Breen +5 more
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Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. [PDF]
PLoS ONE, 2012 BACKGROUND: Retinoids are a class of compounds that are chemically related to vitamin A, which is an essential nutrient that plays a key role in vision, cell growth and differentiation. In vivo, retinoids must bind with specific proteins to perform their
Yu-Ru Zhang, Yu-Qi Zhao, Jing-Fei Huang
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Radioimmunoassay of human plasma retinol-binding protein [PDF]
Journal of Clinical Investigation, 1970 A radioimmunoassay for human plasma retinol-binding protein (RBP) has been developed utilizing a double antibody precipitation technique. RBP was purified 1500- to 2000-fold by procedures described previously. A specific anti-human RBP antiserum was prepared in rabbits by three once-weekly injections of purified RBP emulsified with Freund's adjuvant ...
F R, Smith, A, Raz, D S, Goodman
openaire +2 more sources
Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. [PDF]
PLoS ONE, 2014 BACKGROUND: Bypass of foregut secreted factors promoting insulin resistance is hypothesized to be one of the mechanisms by which resolution of type 2 diabetes (T2D) follows roux-en-y gastric bypass (GBP) surgery.
Mia Jüllig +8 more
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Biochemistry and Biophysics Reports, 2021 The choice of treatment for primary nephrotic syndrome depends on the pathologic type of the disorder. Renal biopsy is necessary for a definitive diagnosis, but it is burdensome for the patients, and can be avoided if tests could be performed using urine
Akira Araumi +7 more
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Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]
, 2012 Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V +9 more
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An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. [PDF]
PLoS ONE, 2013 Adaptation to hypobaric hypoxia is required by animals and human in several physiological and pathological situations. Hypobaric hypoxia is a pathophysiological condition triggering redox status disturbances of cell organization leading, via oxidative ...
Yasmin Ahmad +5 more
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Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner. [PDF]
PLoS ONE, 2013 Dengue constitutes a global health concern. The clinical manifestation of this disease varies from mild febrile illness to severe hemorrhage and/or fatal hypovolemic shock.
Emiliana M Silva +4 more
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