Structure-guided screening of FAR-1 antagonists with multi-stage anthelmintic activity [PDF]
Antimicrobial Agents and ChemotherapyFatty acid and retinol binding proteins (FARs) are nematode-specific proteins that orchestrate lipid metabolism, development, and host immune response.
Juan Wen +9 more
doaj +2 more sources
In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequences [PDF]
FEBS Letters, 1992 The synthetic retinoid fenretinide (4‐HPR; N‐[4‐hydroxyphenyl] all‐trans‐retinamide) interacts with plasma apo‐retinol‐binding protein (RBP)to form a tight complex (λH J = 0.2 μM) which does not exhibit binding affinity to transthyretin (TTR). Therefore, a substantial modification of the retinol hydroxyl group does not appear to affect the interaction ...
Rodolfo Berni +2 more
exaly +3 more sources
Release of retinol and denaturation of its plasma carrier, retinol-binding protein
Folding & Design, 1998 Retinol is tightly packed inside the structure of its plasma carrier (retinol-binding protein, RBP). It was found that retinol release from RBP to aqueous solutions is facilitated by either very low pH or very high temperatures (i.e. by non-physiological conditions that cause protein denaturation).
Andrea Fantuzzi +2 more
exaly +3 more sources
Nanomaterials, 2023 Carboranes are promising agents for applications in boron neutron capture therapy (BNCT), but their hydrophobicity prevents their use in physiological environments.
Tainah Dorina Marforio +3 more
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Production of functional human vitamin A transporter/RBP receptor (STRA6) for structure determination. [PDF]
PLoS ONE, 2015 STRA6 is a plasma membrane protein that mediates the transport of vitamin A, or retinol, from plasma retinol binding protein (RBP) into the cell. Mutations in human STRA6 are associated with Matthew-Wood syndrome, which is characterized by severe ...
Conor J Breen +5 more
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Retinoid-binding proteins: similar protein architectures bind similar ligands via completely different ways. [PDF]
PLoS ONE, 2012 BACKGROUND: Retinoids are a class of compounds that are chemically related to vitamin A, which is an essential nutrient that plays a key role in vision, cell growth and differentiation. In vivo, retinoids must bind with specific proteins to perform their
Yu-Ru Zhang, Yu-Qi Zhao, Jing-Fei Huang
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Radioimmunoassay of human plasma retinol-binding protein [PDF]
Journal of Clinical Investigation, 1970 A radioimmunoassay for human plasma retinol-binding protein (RBP) has been developed utilizing a double antibody precipitation technique. RBP was purified 1500- to 2000-fold by procedures described previously. A specific anti-human RBP antiserum was prepared in rabbits by three once-weekly injections of purified RBP emulsified with Freund's adjuvant ...
F R, Smith, A, Raz, D S, Goodman
openaire +2 more sources
Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. [PDF]
PLoS ONE, 2014 BACKGROUND: Bypass of foregut secreted factors promoting insulin resistance is hypothesized to be one of the mechanisms by which resolution of type 2 diabetes (T2D) follows roux-en-y gastric bypass (GBP) surgery.
Mia Jüllig +8 more
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Biochemistry and Biophysics Reports, 2021 The choice of treatment for primary nephrotic syndrome depends on the pathologic type of the disorder. Renal biopsy is necessary for a definitive diagnosis, but it is burdensome for the patients, and can be avoided if tests could be performed using urine
Akira Araumi +7 more
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An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. [PDF]
PLoS ONE, 2013 Adaptation to hypobaric hypoxia is required by animals and human in several physiological and pathological situations. Hypobaric hypoxia is a pathophysiological condition triggering redox status disturbances of cell organization leading, via oxidative ...
Yasmin Ahmad +5 more
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