Results 51 to 60 of about 3,842,056 (196)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin' [PDF]

, 2005
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin.
Guild, Simon, Lissa R. Herron, Brophy, Peter J, Prystowsky, Michael B., Margaret Brandwein-Gensler, Michael B. Prystowsky, Gavin I. Welsh, Gunn-Moore, Frank J., Venkateswarlu, Kanamarlapudi, Tavaré, Jeremy M, Tavaré, Jeremy M., Gunn-Moore, Francis James, Frank J. Gunn-Moore, Tavaré, JM, Herron, Lissa R, Herron, Lissa R., Gillespie, Stewart, Brannigan, Frances, Prystowsky, M, Stewart Gillespie, Prystowsky, Michael B, Welsh, Gavin I., Frances Brannigan, Tavare, J, Welsh, Gavin I, Welsh, GI, Prystowsky, MB, Kanamarlapudi Venkateswarlu, Brophy, P, Herron, LR, Simon Guild, Brandwein-Gensler, M, Madan, R, Peter J. Brophy, Gunn-Moore, FJ, Gillespie, S, Brophy, Peter J., Rashna Madan, Brannigan, F, Welsh, G, Gunn-Moore, Frank J, Brandwein-Gensler, Margaret, Venkateswarlu, K, Guild, S, Madan, Rashna, Jeremy M. Tavaré, Brophy, PJ, Herron, L, Venkat Kanamarlapudi   +48 more
core   +1 more source

Association of Polyunsaturated Fatty Acids and Incident Glaucoma: The UK Biobank, Multi Omics, and Therapeutic Strategies Study

Medicine Bulletin, EarlyView.
ABSTRACT Purpose To investigate the associations and causal effects of polyunsaturated fatty acids (PUFAs) with incident glaucoma and identify intervention thresholds and therapeutic strategies. Methods This prospective study included 451,199 glaucoma‐free UK Biobank participants of European ancestry.
Jianming Xu, Yuelan Gao, Jun Yu, Yuzhou Zhang, Chi Pui Pang, Clement C. Tham, Jason C. Yam, Li Jia Chen   +7 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

The Interaction of Human Plasma Retinol-binding Protein with Prealbumin

Journal of Biological Chemistry, 1973
Abstract The interaction of human plasma retinol-binding protein with plasma prealbumin was studied by the techniques of velocity ultracentrifugation and polarization of retinol fluorescence. In the first method the unbound fraction of retinol-binding protein, which sediments more slowly than its complexes with prealbumin, was measured by its ...
Pieter P. van Jaarsveld, Harold Edelhoch, DeWitt S. Goodman, Jacob Robbins   +3 more
openaire   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Schwaner, I., Frank, R., Gausepohl, H., Seifert, Roland, Schultz, Günter, Klinz, F. J.   +5 more
core   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

The road not taken: Less traveled roads from the TGN to the plasma membrane [PDF]

, 2015
: The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma
Anne Spang, Spang, Anne
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source