Results 51 to 60 of about 2,787,959 (208)

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Deciphering protein dynamics changes along the pathway of retinol uptake by cellular retinol-binding proteins 1 and 2

, 2018
Four Cellular Retinol-binding Proteins (CRBP 1, 2, 3, 4) are encoded in the human genome. CRBP 1 and 2, sharing a 56% amino acid sequence identity, exhibit the highest binding affinities for retinol.
Rodolfo Berni, Ilaria Menozzi, Eugenia Polverini, Berni, Rodolfo, Polverini, Eugenia, Menozzi, Ilaria   +5 more
core   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Genus-level evolutionary relationships of FAR proteins reflect the diversity of lifestyles of free-living and parasitic nematodes

BMC Biology, 2021
Background Nematodes are a widespread and diverse group comprising free-living and parasitic species, some of which have major detrimental effects on crops, animals, and human health. Genomic comparisons of nematodes may help reveal the genetic bases for
Dongjuan Yuan, Song Li, Ziyu Shang, Muchun Wan, Yu Lin, Yanhua Zhang, Yaoyu Feng, Lian Xu, Lihua Xiao   +8 more
doaj   +1 more source

Retinol binding protein in rat testicular cells [PDF]

Reproduction, 1981
Summary. Cellular retinol-binding protein (CRBP) was identified in the cytosols of cultured Sertoli cells and peritubular cells from the testes of 20-day-old rats. CRBP was not detected in spermatids or spermatocytes obtained from the testes of 60-day-old rats.
J, Huggenvik, M D, Griswold
openaire   +2 more sources

Presence of cellular retinol and retinoic acid‐binding proteins in epidermoid carcinoma of the oral cavity and oropharynx

, 1982
Epidermoid carcinomas of the oral cavity and oropharynx from six patients were examined for the presence and amount of cellular retinol (CRBP) and cellular retinoic acid‐binding (CRABP) proteins. In all cases adjacent, grossly normal tissue was similarly
Goodwin, W. Jarrard, Griffin, A. Clark, Jesse, Richard H, Ong, David E   +3 more
core   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. [PDF]

PLoS ONE, 2013
Adaptation to hypobaric hypoxia is required by animals and human in several physiological and pathological situations. Hypobaric hypoxia is a pathophysiological condition triggering redox status disturbances of cell organization leading, via oxidative ...
Yasmin Ahmad, Narendra K Sharma, Iti Garg, Mohammad Faiz Ahmad, Manish Sharma, Kalpana Bhargava   +5 more
doaj   +1 more source

Binding of synthetic analogues of retinol and retinoic acid (CD-270 derivatives) to retinoid-binding proteins.

, 1991
Cellular retinoid-binding proteins play an important physiological role in the mode of action of retinoids upstream from the nuclear receptors. Tritiated analogues of retinol (ROL) and retinoic acid corresponding to substituted benzo[b]thiophene (CD-270)
Siegenthaler G, Saurat JH
core   +1 more source

Retinol-binding protein 4 in polycystic ovary syndrome--association with steroid hormones and response to pioglitazone treatment [PDF]

, 2009
CONTEXT: Polycystic ovary syndrome (PCOS) is frequently associated with insulin resistance. OBJECTIVE: The aim of the study was to investigate a putative role of the adipokines retinol-binding protein 4 (RBP4), adiponectin, and visfatin in a cohort of ...
Aigner, Elmar, Patsch, Wolfgang, Bachofner, Nora, Klein, Kerstin, Datz, Christian, Hohla, Florian, De Geyter, Christian   +6 more
core   +1 more source