Results 91 to 100 of about 2,787,959 (208)

Retinol-Binding Protein Interferes with Transthyretin-Mediated β‑Amyloid Aggregation Inhibition

, 2018
β-Amyloid (Aβ) aggregation is causally linked to Alzheimer’s disease. On the basis of in vitro and transgenic animal studies, transthyretin (TTR) is hypothesized to provide neuroprotection against Aβ toxicity by binding to Aβ and inhibiting its ...
Regina M. Murphy, Regina M. Murphy (1553098), Parth Mangrolia, Parth Mangrolia (5578865)   +3 more
core   +1 more source

Iterative phase retrieval in macromolecular crystal diffraction using the gradients of intensities

Journal of Applied Crystallography, EarlyView.
Incorporating molecular intensity gradients into an iterative projection algorithm enables model‐free electron‐density reconstruction even for low‐solvent macromolecular crystals.Iterative phase retrieval (IPR) offers a model‐independent route to crystallographic structure determination but is fundamentally limited by the sampling of the diffraction ...
Sebastian Bielfeldt, Oleksandr Yefanov, Matthias Mnich, Henry N. Chapman   +3 more
wiley   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Structure and tissue distribution of some retinoid-binding proteins [PDF]

, 1983
Vitamin A has, apart from its function in the visual pigments, general effects on several organs. Early signs of vitamin A deficiency include keratinization of epithelia and hyperkeratosis of the skin.
Peterson, P. A., Eriksson, U., Nilsson, M., Jönsson, K. H., Liljas, A., Rask, L., Newcomer, M., Sundelin, J., Das, S., Ronne, H., Norlinder, H., Das, K., Busch, C., Kämpe, O., Laurent, B.   +14 more
core   +1 more source

Structural and biochemical basis for retinol‐binding protein 4 antagonism by tinlarebant

British Journal of Pharmacology, EarlyView.
Background and Purpose Retinol‐binding protein 4 (RBP4) is a member of the lipocalin superfamily that is connected to disease states such as insulin resistance, fatty liver disease and ocular disorders including Stargardt disease. Several retinoid and non‐retinoid antagonists of this protein have been developed for potential clinical use, but none have
Marco Bassetto, Philip D. Kiser
wiley   +1 more source

Retinol-binding protein is synthesized in the mammalian eye

Biochemical and Biophysical Research Communications, 1988
As the chromophoric component of the visual pigment, retinol plays an essential role in vision. In the plasma, retinol is transported by retinol-binding protein (RBP) in complex with transthyretin (TTR, prealbumin). In previous work we demonstrated intraocular synthesis of TTR.
R L, Martone, E A, Schon, D S, Goodman, D R, Soprano, J, Herbert   +4 more
openaire   +2 more sources

The Ov20 protein of the parasitic nematode Onchocerca volvulus - A structurally novel class of small helix-rich retinol-binding proteins

, 1997
Ov20 is a major antigen of the parasitic nematode Onchocerca volvulus, the causative agent of river blindness in humans, and the protein is secreted into the tissue occupied by the parasite.
Price, Nicholas C., Cooper, Alan, Bradley, Jannette E., Goodrick, Lucy E., Kennedy, Malcolm W., Brass, Andrew, Garside, Lisa H., McDermott, Lindsay, Kelly, Sharon M.   +8 more
core   +1 more source

Vitamin A, cancer treatment and prevention: The new role of cellular retinol binding proteins [PDF]

, 2015
Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis and play an important physiologic role in a wide range of biological processes. Retinol is obtained from foods of animal origin.
Passeri, D, COSTANZA, GAETANA, Doldo, E, DOLDO, ELENA, Agostinelli, S, Ferlosio, A, FERLOSIO, AMEDEO, ORLANDI, AUGUSTO, ARCURI, GAETANO, Tarquini, C, Arcuri, G, SCIOLI, MARIA GIOVANNA, Orlandi, A, Costanza, G, Scioli, Mg   +14 more
core   +1 more source

Cardiometabolic Protein Profile Changes During Gender‐Affirming Hormone Therapy: A Prospective Clinical Study

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Cardiovascular disease (CVD) risk is elevated in transgender individuals during gender‐affirming hormone therapy (GAHT) with expected different mechanisms between T‐ and E2‐based GAHT. We investigated prospective changes in cardiometabolic proteins relating to complement, inflammation, and transport during GAHT.
Emilie Bukh Madsen, Louise Lehmann Christensen, Sara Ravn Bach, Louise Skøttrup Christiansen, Mathilde Kamp Nørlund, Tine Taulbjerg Kristensen, Guy T'Sjoen, Anne Pernille Hermann, Camilla Viola Buskbjerg Palm, Jan Frystyk, Marianne Skovsager Andersen, Martin Overgaard, Dorte Glintborg   +12 more
wiley   +1 more source

Sex-specific associations of serum retinol-binding protein 4 with type 2 inflammatory biomarkers and pulmonary function in adults with asthma

The Egyptian Journal of Bronchology
Background Retinol-binding protein 4 (RBP4) has been linked to immune regulation, but whether its associations with type 2 inflammatory biomarkers (eosinophils and immunoglobulin E (IgE)) and pulmonary function differ by sex in asthma remains unknown ...
Rasha AL-Darraji, Zahraa Abdulaali Al-Mudhafar   +1 more
doaj   +1 more source