Results 81 to 90 of about 1,339,271 (291)

Molecular basis for retinol binding by serum amyloid A during infection

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Vitamin A is an essential nutrient for immune system development and function. After absorption from the diet, vitamin A is converted to retinol, which is delivered to cells and tissues by retinol-binding proteins.
Zehan Hu, Ye-Ji Bang, K. Ruhn, Lora V. Hooper   +3 more
semanticscholar   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Schwaner, I., Frank, R., Gausepohl, H., Seifert, Roland, Schultz, Günter, Klinz, F. J.   +5 more
core   +1 more source

Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells. [PDF]

PLoS ONE, 2017
Upon breaching of the endometrial surface epithelium, the implanting embryo embeds in the decidualizing stroma. Retinoic acid (RA), a metabolite of vitamin A, is an important morphogen during embryonic and fetal development, although the role of the RA ...
Rie Ozaki, Keiji Kuroda, Yuko Ikemoto, Asako Ochiai, Akemi Matsumoto, Jun Kumakiri, Mari Kitade, Atsuo Itakura, Joanne Muter, Jan J Brosens, Satoru Takeda   +10 more
doaj   +1 more source

Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: effects on retinoid metabolism, function and related diseases

Pharmacology and Therapeutics, 2017
Cellular binding-proteins (BP), including CRBP1, CRBP2, CRABP1, CRABP2, and FABP5, shepherd the poorly aqueous soluble retinoids during uptake, metabolism and function.
J. L. Napoli
semanticscholar   +1 more source

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

AU-rich RNA binding proteins in hematopoiesis and leukemogenesis

, 2011
Posttranscriptional mechanisms are now widely acknowledged to play a central role in orchestrating gene-regulatory networks in hematopoietic cell growth, differentiation, and tumorigenesis.
Baou, M., Murphy, J.J., John D. Norton, John J. Murphy, Norton, J.D., Maria Baou   +5 more
core   +1 more source

Levels of cellular retinol-binding proteins in the small intestine of rats during pregnancy and lactation.

Journal of Lipid Research, 1989
The movement and metabolism of vitamin A is dependent on a number of specific carrier proteins. The small intestine contains both cellular retinol-binding protein (type two) (CRBP(II], restricted to the villus-associated enterocytes, and cellular retinol-
T C Quick, D E Ong
doaj   +1 more source

Urinary Tamm‐Horsfall protein, albumin, vitamin D‐binding protein, and retinol‐binding protein as early biomarkers of chronic kidney disease in dogs

Physiological Reports, 2017
Proteinuria is a marker and mediator of chronic kidney disease (CKD). In clinical practice, the urinary protein‐to‐creatinine ratio (UP/C) is of limited usefulness, because it indicates only the magnitude of proteinuria and not the origin of the loss ...
F. Chacar, M. Kogika, T. Sanches, D. Caragelasco, C. Martorelli, C. Rodrigues, J. M. Capcha, D. Chew, L. Andrade   +8 more
semanticscholar   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source