Results 151 to 160 of about 5,652,471 (282)

Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting

EMBO Reports
Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively from hepatocytes, thereby mobilizing hepatic retinoid stores that ...
Julia S Steinhoff, Carina Wagner, Henriette E Dähnhardt, Kristina Košić, Yueming Meng, Ulrike Taschler, Laura Pajed, Na Yang, Sascha Wulff, Marie F Kiefer, Konstantin M Petricek, Roberto E Flores, Chen Li, Sarah Dittrich, Manuela Sommerfeld, Hervé Guillou, Andrea Henze, Jens Raila, Sylvia J Wowro, Gabriele Schoiswohl, Achim Lass, Michael Schupp   +21 more
doaj   +1 more source

Alcohol‐Associated Liver Disease: Epidemiology, Pathogenesis, and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
ALD imposes a growing global burden influenced by alcohol consumption, genetic susceptibility, and obesity. Its pathogenesis involves interactions among ethanol metabolism, oxidative stress, innate immune activation, regulated cell death, and disruption of the gut–liver axis.
Shuyan Wang, Yirui Hu, Huikuan Chu
wiley   +1 more source

DreamFold: A World Model to efficiently generate protein folding pathways in the latent space

Protein Science, Volume 35, Issue 11, November 2026.
Abstract While there is an abundance of static data for the structure of biological macromolecules, the data regarding their folding mechanisms and dynamics is scarce, posing a challenge to the training of AI models. The World Model approach, which has been very successful in robotics, can come in handy in this regard. From limited data, it can build a
Alan Ianeselli, Jewon Im, Eddie Cavallin, Mark B. Gerstein   +3 more
wiley   +1 more source

Identification, retinoid binding and X-ray analysis of a novel human retinol-binding protein

, 2001
Two cellular retinol-binding proteins (CRBP I and II) with distinct tissue distributions and retinoid-binding properties have been recognized thus far in mammals. Here, we report the identification of a human retinol-binding protein resembling type I (55.
CALDERONE V, STOPPINI M, FOLLI C, BERNI R., ZANOTTI, GIUSEPPE, BOLCHI A, STOPPINI, MONICA, OTTONELLO S, ZANOTTI G   +8 more
core   +1 more source

Multi‐Omics Reveals STAT1 as a Central Regulator of Oxidative Stress‐Induced Senescence in the Aging Retina

Aging Cell, Volume 25, Issue 11, November 2026.
Integrated multi‐omics identifies STAT1 as a central regulator of retinal aging, linking oxidative stress, inflammation, and senescence at neuro‐glial interfaces. ABSTRACT Aging is the dominant risk factor for retinal neurodegeneration, yet the upstream regulators that coordinate senescence‐associated programs across retinal cell types remain ...
Yiran Fan, Ying Li, Xueying Wu, Lin Cai, Ruotong Yang, Zhenhui Liu, Yan Li, Bingtao Hao, Bo Lei, Xiuxiu Jin   +9 more
wiley   +1 more source

Retinol and retinol-binding protein stabilize transthyretin via formation of retinol transport complex.

, 2010
Transthyretin (TTR) is a plasma hormone carrier protein associated with hereditary and senile forms of systemic amyloid disease, wherein slow tetramer disassembly is thought to be an obligatory step. Plasma transport of retinol is carried out exclusively
Robinson, Carol V, Carol V. Robinson, Stéphanie Deroo, Deroo, Stéphanie, Hyung, Suk-Joon, Suk-Joon Hyung   +5 more
core   +1 more source

Nature and properties of retinol-binding proteins [PDF]

Biochemical Journal, 1971
W, Kirby, G, White, J, Glover
openaire   +2 more sources

Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness

, 2010
Objective: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. While retinol is associated with various cardiovascular risk factors, the relation between retinol, RBP4, TTR and carotid ...
Andreas F.H. Pfeiffer, Bobbert, Thomas, Franziska Schwarz, Thomas Bobbert, Knut Mai, Andrea Henze, Florian J. Schweigert, Joachim Spranger, Spranger, Joachim (Prof. Dr. med.), Mai, Knut, Jens Raila, Schwarz, Franziska, Pfeiffer, Andreas F. H. (Prof. Dr.), Schweigert, Florian Johannes (Prof. Dr.), Raila, Jens (Prof. Dr.), Henze, Andrea (Dr.)   +15 more
core   +1 more source

Crystallographic Studies on Complexes Between Retinoids and Retinol-Binding Protein

, 1994
The three-dimensional structures of complexes between bovine plasma retinol-binding protein (RBP) and three retinol analogs with different end groups (fenretinide, all-trans retinoic acid, and axerophthene) have been determined to 1.8-1.9-Angstrom ...
FOLLI C., ZANOTTI, GIUSEPPE, BERNI R., MARCELLO M., SARTORI G., MALPELI G.   +5 more
core  

Retinol‐binding protein in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1981
S, Todesco, L, Punzi, A, Meani, P F, Gambari, A, Borsatti   +4 more
openaire   +2 more sources