Results 111 to 120 of about 1,758,910 (244)

Integrative Bioinformatics, Experimental Validation, and Interpretable Machine Learning Reveal Oxyresveratrol‐Mediated Protection Against Cadmium‐Induced Lung Adenocarcinoma‐Related Transcriptional Dysregulation

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a toxic heavy metal strongly implicated in lung adenocarcinoma (LUAD) through mechanisms involving oxidative stress, epigenetic dysregulation, and chronic inflammation. This study aimed to identify Cd‐responsive genes associated with LUAD and to evaluate the protective effects of oxyresveratrol (O‐RES) against Cd‐induced ...
Murat Isıyel, Hamid Ceylan, Yeliz Demir
wiley   +1 more source

Husbandry factors are associated with skin, gastrointestinal and ophthalmic disorders in leopard geckos (Eublepharis macularius)

Veterinary Record, EarlyView.
Abstract Background Research into disorders in captive reptiles is notably sparse in the UK, despite the popularity of various species as pets. This study aimed to survey and investigate risk factors for disorders of leopard geckos in the UK. Methods Medical records for leopard geckos presenting at three veterinary practices between 2019 and 2023 were ...
Joshua Henley, Tom Dutton, Joanna Hedley
wiley   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Effect of transport length on in vivo oxidative status and breast meat characteristics in outdoor-reared chicken genotypes

Italian Journal of Animal Science, 2016
The aim of the study was to evaluate the effect of transport length on in vivo oxidative status and breast meat characteristics in two chicken genotypes reared under free range conditions.
Cesare Castellini, Simona Mattioli, Luca Piottoli, Alice Cartoni Mancinelli, David Ranucci, Raffaella Branciari, Monica Guarino Amato, Alessandro Dal Bosco   +7 more
doaj   +1 more source

Histological manifestations of vitamin A toxicity in the liver

Histopathology, EarlyView.
Analysing clinicopathological data from 1960 to 2025, this study characterizes the spectrum of liver injury associated with chronic vitamin A toxicity. Hepatic stellate cell hypertrophy/hyperplasia and sinusoidal fibrosis emerge as the predominant features, providing a morphological basis for diagnosing vitamin A hepatotoxicity.
Giorgio Cazzaniga, Georg Lietz, Dina G. Tiniakos   +2 more
wiley   +1 more source

CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3

Open Biology
The vertebrate visual cycle hinges on enzymatically converting all-trans-retinol (at-ROL) into 11-cis-retinal (11c-RAL), the chromophore that binds to opsins in photoreceptors, forming light-responsive pigments.
Vineeta Kaushik, Luca Gessa, Nelam Kumar, Matyáš Pinkas, Mariusz Czarnocki-Cieciura, Krzysztof Palczewski, Jiří Nováček, Humberto Fernandes   +7 more
doaj   +1 more source

Evaluating the suitability of six hydrophobic natural eutectic solvents as the internal phase in a cosmetic cream formulation

International Journal of Cosmetic Science, EarlyView.
Hydrophobic natural eutectic solvents can function as structural oil phase substitutes in creams prepared by low‐energy processes, enabling sustainable, regulation‐compliant formulations with desirable sensory profiles. Abstract Objective This work evaluates whether hydrophobic natural eutectic solvents can replace the conventional oil phase in ...
A. Verger, R. Grard, E. Vrignaud, X. Perse, S. Bouderbala, L. Boudesocque‐Delaye, M. Grisel, E. Gore, E. Munnier   +8 more
wiley   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Changing the climate of public transport : a design research initiative

, 2007
The Public Transport Design Research Initiative, developed by Monash University’s Faculty of Art & Design and the Institute of Transport Studies in 2005, aims to develop original and innovative design concepts and approaches to address the challenges ...
Coxon, Selby, Napper, Robbie, Allen, Jonathon (R13609)   +2 more
core  

Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells

Journal of Lipid Research, 2007
The purpose of this study was to compare the mechanisms of intestinal retinol (ROL) and carotenoid transport. When differentiated Caco-2 cells were incubated with ROL for varying times, cellular ROL plateaued within 2 h, whereas retinyl ester (RE ...
Alexandrine During, Earl H. Harrison
doaj   +1 more source