Results 171 to 180 of about 14,977 (211)

Retinol Transport and Metabolism in Transthyretin-“Knockout” Mice

Nutrition Reviews, 2009
Mice were made deficient in transthyretin (TTR), the protein that normally transports plasma retinol complexed with retinol-binding protein (RBP), by targeted mutagenesis (TTR-knockout mice). The TTR- mice were healthy and fertile, despite extremely low plasma retinol and RBP levels (6% of wild type).
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Inter- and Intracellular Transport of Retinol in the Liver

1986
Following absorption and esterification by enterocytes in the small intestine, retinol is transported in lymph in chylomicrons [1]. In rats, the retinyl esters are relatively nonexchangeable components of the chylomicrons and their remnants [2]. Accordingly, nearly all the retinyl esters follow the chylomicron remnants when they are taken up by the ...
Rune Blomhoff, Kaare R. Norum, Trond Berg   +2 more
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Disturbance of retinol transportation causes nitrofen-induced hypoplastic lung

Journal of Pediatric Surgery, 2007
Retinoids play a key role in lung development. Recent studies suggest that retinoid signalling pathway may be disrupted in the nitrofen model of congenital diaphragmatic hernia (CDH), but the exact mechanism is not clearly understood. We hypothesized that nitrofen interferes with cellular uptake of retinol during lung morphogenesis and therefore ...
Nana, Nakazawa, Sandra, Montedonico, Hajime, Takayasu, Francesca, Paradisi, Prem, Puri   +4 more
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Vitamin A Transport and Retinol-Binding Protein Metabolism

1975
Publisher Summary This chapter elaborates the vitamin A transport and retinol-binding protein (RBP) metabolism. Vitamin A is a compound that exerts a number of important biological effects. In general, the vitamin is necessary for the support of growth and life of higher animals, since in the absence of vitamin A higher animals cease to grow, and in ...
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Transport across liquid membranes containing vitamin A (retinol acetate)

Journal of Colloid and Interface Science, 2004
The role of the surface activity of vitamin A has been studied in the light of the liquid membrane hypothesis of drug action. Transport of relevant amino acids such as serine, threonine, arginine, and histidine and various ions such as calcium, sodium, and potassium in the presence of liquid membranes generated by vitamin A has been studied.
A N, Nagappa, P L, Kole, P V, Pandi, K, Zeeyauddin, R T, Patil, I, Shanmukha   +5 more
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Specificity of the Retinol Transporter of the Rat Small Intestine Brush Border

Biochemistry, 1994
The uptake of vitamin A (all-trans-retinol) by the absorptive cell of the small intestine is the necessary first step in its utilization by the organism and appears to involve a specific carrier that operates by facilitated diffusion. We investigated the specificity of that process by determining the absorption of all-trans-, 13-cis-, and 9-cis-retinol,
S E, Dew, D E, Ong
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Retinol-Binding Protein: The Serum Transport Protein for Vitamin A*

Endocrine Reviews, 1989
The information available regarding the chemical structure of RBP, the structure of the RBP gene, and the expression of the RBP gene has expanded dramatically in recent years. Still many questions concerning RBP remain to be answered. The longstanding and important questions concerning the possible existence and the biochemical characteristics of the ...
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Placental Transport of Retinol in Ewes Fed High Intakes of Vitamin A

The Journal of Nutrition, 1985
Twelve ewes were fed retinyl propionate equivalent to 12,000 micrograms retinol/kg body weight per day for the last two trimesters of pregnancy (group fed high vitamin A). Four ewes received a control level of 120 micrograms/kg body weight per day. Indwelling catheters were implanted surgically in fetal jugular veins and carotid arteries. Ewes or fetal
S, Donoghue, D W, Richardson, D, Sklan, D S, Kronfeld   +3 more
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Effects of fasting and 3,3′,4,4′,5,5′‐hexabromobiphenyl on plasma transport of thyroxine and retinol: Fasting reverses elevation of retinol

Journal of Toxicology and Environmental Health, 1994
Male Wistar rats were injected ip with 0 or 20 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl and blood samples were collected 1, 3, 6, 7, and 8 d later. At 8 d after the injection, serum retinol was increased 30% and serum thyroxine was decreased 26% relative to control values.
P A, Spear, P, Higueret, H, Garcin
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[Retinol transport into the cell nucleus in vitro].

Ukrainskii biokhimicheskii zhurnal (1978), 1999
The retinol interaction with intact cellular nuclei, nuclear envelope and chromatin was investigated. We have shown that the Cellular Retinol-Binding Protein (CRBP) plays a very important role in such interaction. Retinol can specifically interacts with nuclei, nuclear envelope and chromatin only when it presents as a complex with CRBP.
S V, Chetyrkin, L A, Chernukhina, G V, Donchenko   +2 more
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