Results 81 to 90 of about 286,513 (354)

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

Kearns‐Sayre syndrome case. Novel 5,9 kb mtDNA deletion

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
Novel 5,9 kb mtDNA deletion was identified for a 20‐year‐old male who presented with classic Kearns‐Sayre syndrome. Different molecular genetic methods were applied to identify the mitochondrial DNA deletion, but obtaining conflicting research results demonstrated the importance of choosing relevant molecular genetic methods. Abstract Background Kearns‐
Kristina Grigalionienė, Birutė Burnytė, Danutė Balkelienė, Laima Ambrozaitytė, Algirdas Utkus   +4 more
wiley   +1 more source

Looking into Concept Explanation Methods for Diabetic Retinopathy Classification [PDF]

Machine.Learning.for.Biomedical.Imaging. 2 (2024)
Diabetic retinopathy is a common complication of diabetes, and monitoring the progression of retinal abnormalities using fundus imaging is crucial. Because the images must be interpreted by a medical expert, it is infeasible to screen all individuals with diabetes for diabetic retinopathy.
arxiv   +1 more source

Transfer Learning for Retinal Vascular Disease Detection: A Pilot Study with Diabetic Retinopathy and Retinopathy of Prematurity [PDF]

arXiv, 2022
Retinal vascular diseases affect the well-being of human body and sometimes provide vital signs of otherwise undetected bodily damage. Recently, deep learning techniques have been successfully applied for detection of diabetic retinopathy (DR). The main obstacle of applying deep learning techniques to detect most other retinal vascular diseases is the ...
arxiv  

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity. Abstract Purpose To report novel BEST1 variants in six Chinese families with bestrophinopathies of two different inheritance modes and analyze the intrafamilial phenotypic diversity.
Shangying Yang, Zhen Li, Wanyu Cheng, Meijiao Ma, Rui Qi, Xue Rui, Yinghua Ren, Xunlun Sheng, Weining Rong   +8 more
wiley   +1 more source

Explainable and Interpretable Diabetic Retinopathy Classification Based on Neural-Symbolic Learning [PDF]

arXiv, 2022
In this paper, we propose an explainable and interpretable diabetic retinopathy (ExplainDR) classification model based on neural-symbolic learning. To gain explainability, a highlevel symbolic representation should be considered in decision making. Specifically, we introduce a human-readable symbolic representation, which follows a taxonomy style of ...
arxiv  

Long-Term Oral Administration of Salidroside Alleviates Diabetic Retinopathy in db/db Mice

Frontiers in Endocrinology, 2022
Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus, is the leading cause of vision loss in the working-age population worldwide. Unfortunately, current clinical treatments cannot completely prevent the occurrence and development
Fei Yao, Fei Yao, Fei Yao, Xinyi Jiang, Ling Qiu, Ling Qiu, Zixuan Peng, Zixuan Peng, Zixuan Peng, Wei Zheng, Wei Zheng, Wei Zheng, Lexi Ding, Lexi Ding, Lexi Ding, Xiaobo Xia, Xiaobo Xia, Xiaobo Xia   +17 more
doaj   +1 more source

A Patient Centered Intervention to Promote Primary Care Based Screening for Diabetic Retinopathy [PDF]

, 2018
Diabetic Retinopathy is the leading cause of blindness in patient\u27s age 25-74 in the world. Onset of disease is insidious and early intervention is the only way to reduce morbidity.
Earle, William B
core   +1 more source